Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
| ▸ | MRGPRX1 | Q96LB2 | 4/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | BCL2 | P10415 | 1/20 | 0.31 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20262700 | 0.89 | SMN1; SMN2 (0.47) | LMNASMN1; SMN2ALDH1A1KDRKIT | |
| SCHEMBL18342712 | 0.78 | MCL1 (0.43) | LMNASMN1; SMN2MEN1KMT2AMCL1 | |
| SCHEMBL18342662 | 0.76 | SMN1; SMN2 (0.43) | LMNASMN1; SMN2ALDH1A1KDRKIT | |
| SCHEMBL22320501 | 0.73 | SMN1; SMN2 (0.44) | LMNASMN1; SMN2ALDH1A1KDRKIT | |
| SCHEMBL20972715 | 0.70 | NOTUM (0.38) | LMNASMN1; SMN2ALDH1A1KDRLIMK1 | |
| SCHEMBL16815522 | 0.69 | SMN1; SMN2 (0.54) | LMNASMN1; SMN2ALDH1A1KDRKIT | |
| SCHEMBL22320704 | 0.68 | ALDH1A1 (0.41) | LMNASMN1; SMN2ALDH1A1KDRTEK | |
| SCHEMBL20262668 | 0.67 | MCL1 (0.43) | LMNASMN1; SMN2MEN1KMT2AMCL1 | |
| SCHEMBL22320514 | 0.67 | ALDH1A1 (0.36) | LMNASMN1; SMN2ALDH1A1KDRKIT | |
| SCHEMBL20742698 | 0.67 | MAPT (0.43) | LMNASMN1; SMN2ALDH1A1KDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10711010-B2 | Hydroxyester derivatives, a process for their preparation and pharmaceutical compositions containing them | LES LABORATORIES SERVIER (FR) | 2020-07-14 | — | — | US | disclosed |
| EP-3313851-B1 | NEW HYDROXYESTER DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2019-11-06 | — | — | EP | disclosed |
| EP-3405471-B1 | NEW AMMONIUM DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2019-10-30 | — | — | EP | disclosed |
| US-10457689-B2 | Ammonium derivatives, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2019-10-29 | — | — | US | disclosed |
| US-10457687-B2 | Aminoacid derivatives, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2019-10-29 | — | — | US | disclosed |
| US-20190161496-A1 | HYDROXYESTER DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2019-05-30 | — | — | US | disclosed |
| US-10227358-B2 | Hydroxyester derivatives, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2019-03-12 | — | — | US | disclosed |
| US-20190031677-A1 | AMMONIUM DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | VERNALIS (R&D) LTD (GB) | 2019-01-31 | — | — | US | disclosed |
| US-20190031675-A1 | AMINOACID DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2019-01-31 | — | — | US | disclosed |
| EP-3405471-A1 | NEW AMMONIUM DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Les Laboratoires Servier (FR) | 2018-11-28 | — | — | EP | disclosed |
| EP-3313850-B1 | NEW AMINOACID DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2018-10-03 | — | — | EP | disclosed |
| US-20180170947-A1 | HYDROXYESTER DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | VERNALIS (R&D) LTD (GB) | 2018-06-21 | — | — | US | disclosed |
| WO-2017125224-A1 | NEW AMMONIUM DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2017-07-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10227358-B2 | Hydroxyester derivatives, a process for their preparation and pharmaceutical compositions containing them | CASP3, BAX, CASP7 | LMNA 213/4885SMN1; SMN2 2547/4885ALDH1A1 588/4885 |
| US-20180170947-A1 | HYDROXYESTER DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CASP3, BAX, CASP7 | LMNA 213/4885SMN1; SMN2 2547/4885ALDH1A1 588/4885 |
| US-10711010-B2 | Hydroxyester derivatives, a process for their preparation and pharmaceutical compositions containing them | CASP3, BAX, CASP7 | LMNA 213/4885SMN1; SMN2 2547/4885ALDH1A1 588/4885 |
| US-20190031675-A1 | AMINOACID DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BAX, ARG2, ANXA5 | LMNA 77/4885SMN1; SMN2 849/4885ALDH1A1 2999/4885 |
| US-10457689-B2 | Ammonium derivatives, a process for their preparation and pharmaceutical compositions containing them | ARG1, ASS1, ATP6V1B1 | LMNA 3168/4885SMN1; SMN2 4342/4885ALDH1A1 1905/4885 |
| US-20190031677-A1 | AMMONIUM DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ARG1, ASS1, ATP6V1B1 | LMNA 3168/4885SMN1; SMN2 4342/4885ALDH1A1 1905/4885 |
| US-10457687-B2 | Aminoacid derivatives, a process for their preparation and pharmaceutical compositions containing them | BAX, ARG2, ANXA5 | LMNA 77/4885SMN1; SMN2 849/4885ALDH1A1 2999/4885 |
| US-20190161496-A1 | HYDROXYESTER DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CASP3, BAX, CASP7 | LMNA 213/4885SMN1; SMN2 2547/4885ALDH1A1 588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.