Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | KLK7 | P49862 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29307410 | 0.94 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1MAPK1KLK7TDP1 | |
| SCHEMBL9265342 | 0.94 | KLK7 (0.60) | ALDH1A1L3MBTL1MAPK1KLK7TDP1 | |
| SCHEMBL7495579 | 0.94 | KLK7 (0.57) | ALDH1A1L3MBTL1MAPK1KLK7TDP1 | |
| SCHEMBL4065004 | 0.92 | KLK7 (0.59) | ALDH1A1L3MBTL1MAPK1KLK7TDP1 | |
| SCHEMBL11832289 | 0.91 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1MAPK1KLK7TDP1 | |
| SCHEMBL7060349 | 0.90 | ITGB3 (0.49) | ALDH1A1L3MBTL1MAPK1KLK7GLA | |
| SCHEMBL22502940 | 0.87 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1MAPK1KLK7NOTUM | |
| SCHEMBL9105970 | 0.86 | ALDH1A1 (0.51) | ALDH1A1L3MBTL1MAPK1KLK7TDP1 | |
| SCHEMBL19303755 | 0.84 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1MAPK1KMT2ANOTUM | |
| SCHEMBL22525497 | 0.84 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1MAPK1KLK7TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117813308-A | Nitrogen-containing condensed ring compound, preparation method and medical application thereof | 中国医药研究开发中心有限公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-105884607-A | Preparation method of cyclopropylpropionic acid | 上海合全药业股份有限公司 | 2016-08-24 | — | — | CN | disclosed |
| US-8609669-B2 | Potassium channel modulators | ABBVIE INC. (US) | 2013-12-17 | — | — | US | disclosed |
| WO-2012067822-A1 | PYRAZOLO [1, 5 -A] PYRIMIDIN POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2012-05-24 | — | — | WO | disclosed |
| US-20120122888-A1 | Potassium Channel Modulators | ABBOTT LABORATORIES (US) | 2012-05-17 | — | — | US | disclosed |
| US-20110224250-A1 | ISOQUINOLINE DERIVATIVE, AND PDE INHIBITOR COMPRISING SAME AS ACTIVE INGREDIENT | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2011-09-15 | — | — | US | disclosed |
| EP-2351748-A1 | ISOQUINOLINE DERIVATIVE, AND PDE INHIBITOR COMPRISING SAME AS ACTIVE INGREDIENT | Kyorin Pharmaceutical Co., Ltd. (JP) | 2011-08-03 | — | — | EP | disclosed |
| CN-1221535-C | Spiroimidazolidine derivatives, their preparation, their use and pharmaceutical preparations comprising them | AVENTIS PHARMA GMBH (DE) | 2005-10-05 | — | — | CN | disclosed |
| CN-1356986-A | Spiroimidazolidine derivatives, their prepn. their use and pharmaceutical prepns. comprising them | AVENTIS PHARMA GMBH (DE) | 2002-07-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122888-A1 | Potassium Channel Modulators | KCNQ1, KCNQ2, KCNJ2 | ALDH1A1 1773/4885L3MBTL1 1819/4885MAPK1 1526/4885 |
| US-20110224250-A1 | ISOQUINOLINE DERIVATIVE, AND PDE INHIBITOR COMPRISING SAME AS ACTIVE INGREDIENT | PDE5A, PDE2A, PDE3A | ALDH1A1 162/4885L3MBTL1 4824/4885MAPK1 2529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.