Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CETP | P11597 | 3/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10004616 | 0.89 | NPC1 (0.43) | TSHRALDH1A1L3MBTL1NPC1RAB9A | |
| SCHEMBL8310205 | 0.79 | ALDH1A1 (0.50) | ALDH1A1MAPK1L3MBTL1NPC1RAB9A | |
| SCHEMBL5370663 | 0.78 | ALDH1A1 (0.43) | TSHRALDH1A1MAPK1L3MBTL1NPC1 | |
| SCHEMBL4633843 | 0.76 | ENPP2 (0.36) | TSHRALDH1A1MAPK1L3MBTL1PDPK1 | |
| SCHEMBL472178 | 0.73 | ALDH1A1 (0.38) | TSHRALDH1A1L3MBTL1CETPFOLH1 | |
| SCHEMBL4633323 | 0.73 | CETP (0.39) | TSHRALPGPTK2BALDH1A1L3MBTL1 | |
| SCHEMBL20162506 | 0.73 | ALDH1A1 (0.38) | TSHRALDH1A1L3MBTL1CETPFOLH1 | |
| SCHEMBL4271373 | 0.70 | NPC1 (0.46) | TSHRALPGPTK2BALDH1A1MAPK1 | |
| SCHEMBL20856237 | 0.69 | HSD17B10 (0.40) | — | |
| SCHEMBL10004685 | 0.69 | ALDH1A1 (0.40) | TSHRALDH1A1CETPFOLH1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11078221-B2 | Phosphorodiamidates and other phosphorus derivatives of fingolimod and related S1P receptor modulators | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LTD (GB) | 2021-08-03 | — | — | US | disclosed |
| US-20200255460-A1 | PHOSPHORODIAMIDATES AND OTHER PHOSPHORUS DERIVATIVES OF FINGOLIMOD AND RELATED S1 P RECEPTOR MODULATORS | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LTD (GB) | 2020-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11078221-B2 | Phosphorodiamidates and other phosphorus derivatives of fingolimod and related S1P receptor modulators | S1PR1, S1PR3, S1PR4 | TSHR 925/4885ALPG 2159/4885PTK2B 1779/4885 |
| US-20200255460-A1 | PHOSPHORODIAMIDATES AND OTHER PHOSPHORUS DERIVATIVES OF FINGOLIMOD AND RELATED S1 P RECEPTOR MODULATORS | S1PR1, S1PR3, FFAR1 | TSHR 849/4885ALPG 2212/4885PTK2B 1731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.