Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | AGER | Q15109 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4277278 | 0.86 | ENPP2 (0.34) | ENPP2AGERTSHRMEN1ALDH1A1 | |
| SCHEMBL22321972 | 0.76 | TSHR (0.41) | TSHRALDH1A1KMT2AL3MBTL1MAPT | |
| SCHEMBL4268901 | 0.76 | ENPP2 (0.37) | ENPP2AGERTSHRMEN1ALDH1A1 | |
| SCHEMBL4633331 | 0.76 | ENPP2 (0.37) | ENPP2AGERTSHRMEN1ALDH1A1 | |
| SCHEMBL10004616 | 0.70 | NPC1 (0.43) | TSHRALDH1A1L3MBTL1KDM4ENPC1 | |
| SCHEMBL4271373 | 0.66 | NPC1 (0.46) | TSHRALDH1A1L3MBTL1NPC1RAB9A | |
| SCHEMBL4633319 | 0.65 | SLC6A2 (0.39) | TSHRMEN1ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL4276273 | 0.65 | SLC6A2 (0.39) | TSHRMEN1ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL5435739 | 0.65 | L3MBTL1 (0.52) | ENPP2TSHRKMT2AL3MBTL1NPSR1 | |
| SCHEMBL10004685 | 0.65 | ALDH1A1 (0.40) | TSHRALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928475-B1 | ANTIVIRAL PHOSPHORAMIDATES OF 4'-C-AZIDO-SUBSTITUTED PRONUCLEOTIDES | RIBOSCIENCE LLC (US) | 2018-05-23 | — | — | EP | disclosed |
| EP-1928475-A2 | ANTIVIRAL PHOSPHORAMIDATES OF 4'-SUBSTITUTED PRONUCLEOTIDES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007020193-A2 | ANTIVIRAL PHOSPHORAMIDATES OF 4 ' -SUBSTITUTED PRONUCLEOTIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-22 | — | — | WO | disclosed |