Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK8 | O60259 | 2/20 | 0.51 |
| ▸ | PLAU | P00749 | 2/20 | 0.51 |
| ▸ | KLK2 | P20151 | 2/20 | 0.51 |
| ▸ | KLK4 | Q9Y5K2 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | LAP3 | P28838 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20710721 | 0.88 | KLK8 (0.42) | KLK8PLAUKLK2KLK4MEN1 | |
| SCHEMBL563232 | 0.87 | KLK8 (0.63) | KLK8PLAUKLK2KLK4MEN1 | |
| SCHEMBL22321983 | 0.83 | SRC (0.44) | KLK8PLAUKLK2KLK4MEN1 | |
| SCHEMBL22321984 | 0.82 | LTA4H (0.53) | KLK8PLAUKLK2KLK4MEN1 | |
| SCHEMBL28701098 | 0.77 | KLK8 (0.57) | KLK8PLAUKLK2KLK4HTT | |
| SCHEMBL22322100 | 0.77 | CA1 (0.54) | KLK8PLAUKLK2KLK4MEN1 | |
| SCHEMBL17923914 | 0.76 | KLK8 (0.53) | KLK8PLAUKLK2KLK4MEN1 | |
| SCHEMBL4231397 | 0.75 | KLK8 (0.59) | KLK8PLAUKLK2KLK4MEN1 | |
| SCHEMBL916422 | 0.75 | KLK8 (0.59) | KLK8PLAUKLK2KLK4MEN1 | |
| SCHEMBL29267239 | 0.75 | KLK8 (0.59) | KLK8PLAUKLK2KLK4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10927135-B2 | Metal-free direct arylation of dialkyl phosphonates for the synthesis of mixed alkyl aryl phosphonates | THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, LAS VEGAS (US) | 2021-02-23 | — | — | US | disclosed |
| US-20200255461-A1 | METAL-FREE DIRECT ARYLATION OF DIALKYL PHOSPHONATES FOR THE SYNTHESIS OF MIXED ALKYL ARYL PHOSPHONATES | THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, LAS VEGAS | 2020-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200255461-A1 | METAL-FREE DIRECT ARYLATION OF DIALKYL PHOSPHONATES FOR THE SYNTHESIS OF MIXED ALKYL ARYL PHOSPHONATES | SLC35B2, PPIP5K2, PPA1 | KLK8 2953/4885PLAU 4529/4885KLK2 1716/4885 |
| US-10927135-B2 | Metal-free direct arylation of dialkyl phosphonates for the synthesis of mixed alkyl aryl phosphonates | SLC35B2, PPIP5K2, PPA1 | KLK8 2953/4885PLAU 4529/4885KLK2 1716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.