Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | GABRD | O14764 | 1/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.48 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3814817 | 0.84 | HPGD (0.67) | HPGDCA2ALDH1A1 | |
| SCHEMBL8358137 | 0.83 | SIGMAR1 (0.81) | SIGMAR1HPGDMKNK1MKNK2GABRD | |
| SCHEMBL8934917 | 0.82 | SIGMAR1 (0.64) | SIGMAR1HPGDMKNK1MKNK2GABRD | |
| SCHEMBL30798838 | 0.82 | SIGMAR1 (0.68) | SIGMAR1HPGDMKNK1MKNK2GABRD | |
| SCHEMBL3234988 | 0.81 | HRH3 (0.61) | HPGD | |
| SCHEMBL10260239 | 0.81 | SIGMAR1 (0.62) | SIGMAR1HPGDMKNK1MKNK2GABRD | |
| Hydrochloric Acid SCHEMBL25324901 | 0.79 | HPGD (0.63) | SIGMAR1HPGDMKNK1MKNK2GABRD | |
| SCHEMBL8357615 | 0.79 | SIGMAR1 (0.64) | SIGMAR1HPGDMKNK1MKNK2GABRD | |
| SCHEMBL12017808 | 0.78 | GABRD (0.71) | SIGMAR1HPGDMKNK1MKNK2GABRD | |
| SCHEMBL1409459 | 0.78 | SIGMAR1 (0.68) | SIGMAR1HPGDMKNK1MKNK2GABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3921317-A1 | 3-AMINO-2-[2-(ACYLAMINO)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE AS CSNK1 INHIBITORS | Bayer Aktiengesellschaft (DE) | 2021-12-15 | — | — | EP | claimed |
| WO-2020161257-A1 | 3-AMINO-2-[2-(ACYLAMINO)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE AS CSNK1 INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2020-08-13 | — | — | WO | claimed |
| EP-4188551-A1 | ARYL SUBSTITUTED PYRROLO-PYRIDINONES AND THERAPEUTIC USES THEREOF | Bayer Aktiengesellschaft (DE) | 2023-06-07 | — | — | EP | disclosed |