Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CA7 | P43166 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.58 |
| ▸ | CCNC | P24863 | 1/20 | 0.56 |
| ▸ | CDK8 | P49336 | 1/20 | 0.56 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MGLL | Q99685 | 1/20 | 0.51 |
| ▸ | GABRD | O14764 | 1/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.50 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14466291 | 0.93 | SIGMAR1 (0.60) | SIGMAR1HPGDCA12CA1CA2 | |
| SCHEMBL8358137 | 0.90 | SIGMAR1 (0.81) | SIGMAR1HPGDMKNK1MKNK2ALDH1A1 | |
| SCHEMBL20261717 | 0.86 | CA12 (0.73) | HPGDCA12CA1CA2CA7 | |
| SCHEMBL30798838 | 0.85 | SIGMAR1 (0.68) | SIGMAR1HPGDMKNK1MKNK2ALDH1A1 | |
| SCHEMBL8260488 | 0.85 | SIGMAR1 (0.72) | SIGMAR1HPGDCCNCCDK8MKNK1 | |
| SCHEMBL3583338 | 0.85 | HPGD (0.73) | SIGMAR1HPGDCA12CA1CA2 | |
| Tert-Butyl Formate SCHEMBL27751341 | 0.84 | HPGD (0.57) | SIGMAR1HPGDCA12CA1CA2 | |
| SCHEMBL1509718 | 0.84 | SIGMAR1 (0.47) | SIGMAR1HPGDCA12CA1CA2 | |
| SCHEMBL23140495 | 0.83 | SIGMAR1 (0.76) | SIGMAR1HPGDCCNCCDK8MKNK1 | |
| SCHEMBL4505138 | 0.83 | SIGMAR1 (0.70) | SIGMAR1HPGDCCNCCDK8MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116585894-A | Preparation method of photoinitiated polymerization assisted interfacial polymerization high-performance nanofiltration membrane | 哈尔滨工业大学 | 2023-08-15 | — | — | CN | claimed |
| US-5922203-A | AMINE COMPOUND REACTED WITH ACYL HALIDE FOR MEMBRANES | HYDRANAUTICS (US) | 1999-07-13 | — | — | US | claimed |
| CN-119161360-A | Tricyclic heterocyclic derivative and preparation method and application thereof | 浙江省人民医院 | 2024-12-20 | — | — | CN | disclosed |
| CN-116585894-A | Preparation method of photoinitiated polymerization assisted interfacial polymerization high-performance nanofiltration membrane | 哈尔滨工业大学 | 2023-08-15 | — | — | CN | disclosed |
| US-11643416-B2 | Substituted 1′,2′-dihydro-3′H-spiro[cyclohexane-1,4′-pyrimido[5′,4′:4,5]pyrrolo[2,1-c][1,2,4]triazin]-3′-ones as cyclin-dependent kinase inhibitors | G1 THERAPEUTICS, INC. (US) | 2023-05-09 | — | — | US | disclosed |
| US-11643416-B2 | Substituted 1′,2′-dihydro-3′H-spiro[cyclohexane-1,4′-pyrimido[5′,4′:4,5]pyrrolo[2,1-c][1,2,4]triazin]-3′-ones as cyclin-dependent kinase inhibitors | G1 THERAPEUTICS, INC. (US) | 2023-05-09 | — | — | US | disclosed |
| US-20230018460-A1 | 1-AMINOSULFONYL-2-CARBOXYPYRROLE DERIVATIVES AS METALLO-BETA-LACTAMASE INHIBITORS | Infex Therapeutics Limited (GB) | 2023-01-19 | — | — | US | disclosed |
| US-20220008418-A1 | Aminoquinoline Derivatives and Uses Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-01-13 | — | — | US | disclosed |
| EP-3544975-B1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND USE | DANA FARBER CANCER INST INC (US) | 2022-01-05 | — | — | EP | disclosed |
| WO-2021236650-A1 | CYCLIN-DEPENDENT KINASE INHIBITING COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS | G1 THERAPEUTICS, INC. (US) | 2021-11-25 | — | — | WO | disclosed |
| EP-2822936-B1 | AMINOQUINOLINE DERIVATIVES AND USES THEREOF | MCLEAN HOSPITAL CORP (US) | 2021-09-08 | — | — | EP | disclosed |
| US-5922203-A | AMINE COMPOUND REACTED WITH ACYL HALIDE FOR MEMBRANES | HYDRANAUTICS (US) | 1999-07-13 | — | — | US | disclosed |
| US-5922203-A | AMINE COMPOUND REACTED WITH ACYL HALIDE FOR MEMBRANES | HYDRANAUTICS (US) | 1999-07-13 | — | — | US | disclosed |
| EP-0215902-A1 | PROCESS FOR 4-AMINO QUINOLINES | THE UPJOHN COMPANY (US) | 1987-04-01 | — | — | EP | disclosed |
| WO-1986005489-A1 | PROCESS FOR 4-AMINO QUINOLINES | THE UPJOHN COMPANY (US) | 1986-09-25 | — | — | WO | disclosed |
| US-4167567-A | Antihypertensive 4-aminoquinolines | THE UPJOHN COMPANY (US) | 1979-09-11 | — | — | US | disclosed |
| US-4057518-A | Process for the manufacture of heat resistant multicellular materials | RHONE-POULENC INDUSTRIES (FR) | 1977-11-08 | — | — | US | disclosed |
| US-4025629-A | HYPOTENSIVES, ANTIANXIETY | THE UPJOHN COMPANY (US) | 1977-05-24 | — | — | US | disclosed |
| US-4013600-A | STORAGE STABILITY | RHONE-POULENC INDUSTRIES (FR) | 1977-03-22 | — | — | US | disclosed |
| US-4010220-A | AMINO COMPOUND, POLYURETHANE ELASTOMER | RHONE-POULENC INDUSTRIES (FR) | 1977-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220008418-A1 | Aminoquinoline Derivatives and Uses Thereof | LRRK2, NLN, AADAT | SIGMAR1 1896/4885HPGD 879/4885CA12 4878/4885 |
| US-20230018460-A1 | 1-AMINOSULFONYL-2-CARBOXYPYRROLE DERIVATIVES AS METALLO-BETA-LACTAMASE INHIBITORS | CPN1, CMBL, ALDH7A1 | SIGMAR1 2491/4885HPGD 900/4885CA12 2096/4885 |
| US-11643416-B2 | Substituted 1′,2′-dihydro-3′H-spiro[cyclohexane-1,4′-pyrimido[5′,4′:4,5]pyrrolo[2,1-c][1,2,4]triazin]-3′-ones as cyclin-dependent kinase inhibitors | CDK2, CCNI, CCNK | SIGMAR1 4334/4885HPGD 693/4885CA12 4658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.