Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.47 |
| ▸ | PTGES | O14684 | 3/20 | 0.47 |
| ▸ | PPARG | P37231 | 3/20 | 0.47 |
| ▸ | IAPP | P10997 | 3/20 | 0.46 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31256756 | 0.87 | IAPP (0.60) | ALOX5PTGESPPARGIAPPCAPN1 | |
| SCHEMBL2388960 | 0.85 | BACE1 (0.46) | IAPPCAPN1CA2BACE1HSP90AA1 | |
| SCHEMBL2233170 | 0.84 | ALOX5 (0.50) | ALOX5PTGESPPARGIAPPCAPN1 | |
| SCHEMBL2235010 | 0.83 | ALOX5 (0.47) | ALOX5PTGESPPARGIAPPCAPN1 | |
| SCHEMBL27976644 | 0.82 | APP (0.62) | ALOX5PTGESPPARGIAPPCAPN1 | |
| SCHEMBL30839919 | 0.82 | APP (0.62) | ALOX5PTGESPPARGIAPPCAPN1 | |
| SCHEMBL16429273 | 0.82 | APP (0.62) | ALOX5PTGESPPARGIAPPCAPN1 | |
| SCHEMBL16429275 | 0.82 | APP (0.62) | ALOX5PTGESPPARGIAPPCAPN1 | |
| SCHEMBL2931779 | 0.81 | HTR1A (0.57) | ALOX5PTGESCAPN1CA2CA1 | |
| SCHEMBL10635812 | 0.81 | HTR1A (0.57) | ALOX5PTGESCAPN1CA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011093524-A1 | DI - SUBSTITUTED PYRIDINE DERIVATIVES AS ANTICANCERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2011-08-04 | — | — | WO | disclosed |