Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.36 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.36 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 10/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26969211 | 0.91 | SMN1; SMN2 (0.40) | ALDH1A1SMN1; SMN2CYP2C19FAAHEPHX2 | |
| SCHEMBL21977402 | 0.91 | SMN1; SMN2 (0.40) | ALDH1A1SMN1; SMN2CYP2C19FAAHEPHX2 | |
| SCHEMBL9901325 | 0.91 | SMN1; SMN2 (0.40) | ALDH1A1SMN1; SMN2CYP2C19FAAHEPHX2 | |
| SCHEMBL5792677 | 0.88 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2FAAHALDH1A2ALDH2 | |
| SCHEMBL9901593 | 0.86 | FAAH (0.49) | ALDH1A1SMN1; SMN2FAAHEPHX2 | |
| Hydrochloric Acid SCHEMBL11162968 | 0.86 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2FAAHALDH1A2ALDH2 | |
| SCHEMBL935367 | 0.85 | — | — | |
| SCHEMBL21070920 | 0.82 | MEN1 (0.45) | CYP2C19EPHX2MAPK1ACHE | |
| SCHEMBL22207944 | 0.82 | TSHR (0.38) | ALDH1A1SMN1; SMN2CYP2C19FAAHEPHX2 | |
| SCHEMBL16147093 | 0.82 | TSHR (0.38) | ALDH1A1SMN1; SMN2CYP2C19FAAHEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3922632-A1 | TARGET PROTEIN EED DEGRADATION-INDUCING DEGRADUCER, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATED TO EED, EZH2, OR PRC2, COMPRISING SAME AS ACTIVE INGREDIENT | Korea Research Institute of Chemical Technology (KR) | 2021-12-15 | — | — | EP | disclosed |
| WO-2020162725-A1 | TARGET PROTEIN EED DEGRADATION-INDUCING DEGRADUCER, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATED TO EED, EZH2, OR PRC2, COMPRISING SAME AS ACTIVE INGREDIENT | 한국화학연구원 | 2020-08-13 | — | — | WO | disclosed |