Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GLP1R | P43220 | 8/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9901325 | 0.88 | SMN1; SMN2 (0.40) | FAAHSMN1; SMN2ALDH1A1GAATSHR | |
| SCHEMBL26969211 | 0.88 | SMN1; SMN2 (0.40) | FAAHSMN1; SMN2ALDH1A1GAATSHR | |
| SCHEMBL21977402 | 0.88 | SMN1; SMN2 (0.40) | FAAHSMN1; SMN2ALDH1A1GAATSHR | |
| SCHEMBL22326257 | 0.86 | ALDH1A1 (0.43) | FAAHSMN1; SMN2ALDH1A1EPHX2 | |
| SCHEMBL22207944 | 0.85 | TSHR (0.38) | FAAHSMN1; SMN2ALDH1A1GLP1RTSHR | |
| SCHEMBL22207945 | 0.85 | TSHR (0.38) | FAAHSMN1; SMN2ALDH1A1GLP1RTSHR | |
| SCHEMBL16147093 | 0.85 | TSHR (0.38) | FAAHSMN1; SMN2ALDH1A1GLP1RTSHR | |
| SCHEMBL22207986 | 0.85 | TSHR (0.38) | FAAHSMN1; SMN2ALDH1A1GLP1RTSHR | |
| SCHEMBL29060087 | 0.85 | FAAH (0.44) | FAAHSMN1; SMN2GLP1RGAATSHR | |
| SCHEMBL8524743 | 0.84 | FAAH (0.46) | FAAHSMN1; SMN2GAATSHRCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180356421-A9 | Small-Molecule Hydrophobic Tagging of Fusion Proteins and Induced Degradation of Same | UNIV YALE (US) | 2018-12-13 | — | — | US | disclosed |
| US-10145848-B2 | Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same | YALE UNIVERSITY (US) | 2018-12-04 | — | — | US | disclosed |
| US-20170307614-A1 | Small-Molecule Hydrophobic Tagging of Fusion Proteins and Induced Degradation of Same | UNIV YALE (US) | 2017-10-26 | — | — | US | disclosed |
| US-9632089-B2 | Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same | YALE UNIVERSITY (US) | 2017-04-25 | — | — | US | disclosed |
| US-20170067874-A1 | Small-Molecule Hydrophobic Tagging of Fusion Proteins and Induced Degradation of Same | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-03-09 | — | — | US | disclosed |
| US-9500653-B2 | Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same | YALE UNIVERSITY (US) | 2016-11-22 | — | — | US | disclosed |
| US-20140302523-A1 | Small-Molecule Hydrophobic Tagging of Fusion Proteins and Induced Degradation of Same | YALE UNIVERSITY (US) | 2014-10-09 | — | — | US | disclosed |
| EP-2649099-A2 | SMALL-MOLECULE HYDROPHOBIC TAGGING OF FUSION PROTEINS AND INDUCED DEGRADATION OF SAME | Yale University (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078559-A2 | SMALL-MOLECULE HYDROPHOBIC TAGGING OF FUSION PROTEINS AND INDUCED DEGRADATION OF SAME | YALE UNIVERSITY (US) | 2012-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180356421-A9 | Small-Molecule Hydrophobic Tagging of Fusion Proteins and Induced Degradation of Same | HSP90B1, LAMP2, PSMG3 | FAAH 2500/4885SMN1; SMN2 3540/4885ALDH1A1 4257/4885 |
| US-10145848-B2 | Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same | HSP90B1, LAMP2, PSMG3 | FAAH 2500/4885SMN1; SMN2 3540/4885ALDH1A1 4257/4885 |
| US-20170067874-A1 | Small-Molecule Hydrophobic Tagging of Fusion Proteins and Induced Degradation of Same | HSP90B1, LAMP2, PSMG3 | FAAH 2570/4885SMN1; SMN2 3472/4885ALDH1A1 4315/4885 |
| US-20170307614-A1 | Small-Molecule Hydrophobic Tagging of Fusion Proteins and Induced Degradation of Same | HSP90B1, LAMP2, PSMG3 | FAAH 2500/4885SMN1; SMN2 3540/4885ALDH1A1 4257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.