Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.55 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.49 |
| ▸ | CDC7 | O00311 | 3/20 | 0.46 |
| ▸ | MET | P08581 | 2/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.45 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | PRKACA | P17612 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | CDK9 | P50750 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11612594 | 0.81 | AXL (0.55) | AXLGPR84LRRK2KMT2AMAP2K1 | |
| SCHEMBL7935746 | 0.77 | AXL (0.50) | AXLGPR84LRRK2KMT2AMAP2K1 | |
| SCHEMBL858484 | 0.77 | TUBB4A (0.57) | AXLGPR84LRRK2KMT2AMAP2K1 | |
| SCHEMBL857324 | 0.76 | AXL (0.49) | AXLGPR84LRRK2KMT2AMAP2K1 | |
| SCHEMBL856966 | 0.76 | AXL (0.49) | AXLGPR84LRRK2KMT2AMAP2K1 | |
| SCHEMBL12657321 | 0.75 | AXL (0.60) | AXLGPR84LRRK2KMT2AMAP2K1 | |
| SCHEMBL2111969 | 0.75 | AXL (0.60) | AXLGPR84LRRK2KMT2AMAP2K1 | |
| SCHEMBL5618155 | 0.74 | TGFBR1 (0.71) | AXLGPR84LRRK2KMT2AMAP2K1 | |
| SCHEMBL856814 | 0.74 | AXL (0.43) | AXLGPR84LRRK2KMT2AMAP2K1 | |
| SCHEMBL29286701 | 0.74 | AXL (0.46) | AXLGPR84LRRK2KMT2AMAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3141548-B9 | PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES | VERTEX PHARMA (US) | 2020-08-12 | — | — | EP | disclosed |