Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.74 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 8/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264634 | 0.90 | PNMT (0.70) | PNMTDRD2DRD4DRD3TAAR1 | |
| SCHEMBL5366733 | 0.89 | PNMT (0.72) | PNMTDRD2DRD4DRD3NPC1 | |
| SCHEMBL28661205 | 0.88 | PNMT (0.68) | PNMTDRD2DRD4DRD3TAAR1 | |
| SCHEMBL9859906 | 0.87 | PNMT (0.70) | PNMTDRD2DRD4DRD3NPC1 | |
| SCHEMBL6558685 | 0.87 | PNMT (0.70) | PNMTDRD2DRD4DRD3NPC1 | |
| SCHEMBL7603814 | 0.87 | PNMT (0.70) | PNMTDRD2DRD4DRD3NPC1 | |
| SCHEMBL7609046 | 0.87 | PNMT (0.70) | PNMTDRD2DRD4DRD3NPC1 | |
| SCHEMBL4989872 | 0.85 | PNMT (1.00) | PNMTDRD2DRD4DRD3NPC1 | |
| SCHEMBL6674911 | 0.85 | PNMT (0.68) | PNMTDRD2DRD4DRD3NPC1 | |
| Hydrochloric Acid SCHEMBL5357887 | 0.85 | PNMT (0.68) | PNMTDRD2DRD4DRD3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150374730-A1 | CHOLESTANOL DERIVATIVE FOR COMBINED USE | NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY (JP) | 2015-12-31 | — | — | US | disclosed |
| EP-2404608-B1 | CHOLESTANOL DERIVATIVE FOR COMBINED USE | OTSUKA PHARMA CO LTD (JP) | 2015-04-01 | — | — | EP | disclosed |
| US-20140178464-A1 | CHOLESTANOL DERIVATIVE FOR COMBINED USE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-06-26 | — | — | US | disclosed |
| EP-1921086-B1 | ANTITUMOR AGENT | OTSUKA PHARMA CO LTD (JP) | 2014-04-16 | — | — | EP | disclosed |
| EP-2251014-B1 | COMBINATIONS OF AN ANTI-CANCER AGENT AND A CHOLESTANOL DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 2013-11-20 | — | — | EP | disclosed |
| US-20130101679-A1 | CHOLESTANOL DERIVATIVE FOR COMBINED USE | YAZAWA SHIN (JP) | 2013-04-25 | — | — | US | disclosed |
| US-20120015025-A1 | CHOLESTANOL DERIVATIVE FOR COMBINED USE | NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY (JP) | 2012-01-19 | — | — | US | disclosed |
| US-20120009251-A1 | CHOLESTANOL DERIVATIVE FOR COMBINED USE | NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY (JP) | 2012-01-12 | — | — | US | disclosed |
| EP-2404608-A1 | COMBINATION USE OF CHOLESTANOL DERIVATIVE | Otsuka Pharmaceutical Co., Ltd. (JP) | 2012-01-11 | — | — | EP | disclosed |
| US-8088744-B2 | Cholestanol derivative for combined use | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-03 | — | — | US | disclosed |
| EP-2251014-A1 | COMBINED USE OF CHOLESTANOL DERIVATIVE | Otsuka Pharmaceutical Co., Ltd. (JP) | 2010-11-17 | — | — | EP | disclosed |
| US-20100062053-A1 | CHOLESTANOL DERIVATIVE FOR COMBINED USE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2010-03-11 | — | — | US | disclosed |
| US-7465753-B2 | Glycoside-containing liposome | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-12-16 | — | — | US | disclosed |
| EP-1921086-A1 | ANTITUMOR AGENT | Otsuka Pharmaceutical Co., Ltd. (JP) | 2008-05-14 | — | — | EP | disclosed |
| US-20060193903-A1 | Glycoside-containing liposome | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-08-31 | — | — | US | disclosed |
| EP-1647277-A1 | GLYCOSIDE-CONTAINING LIPOSOME | Otsuka Pharmaceutical Company, Limited (JP) | 2006-04-19 | — | — | EP | disclosed |
| EP-0179630-B1 | N6-ACENAPHTHYL ADENOSINES AND ANALOGS THEREOF | WARNER-LAMBERT COMPANY (US) | 1990-03-07 | — | — | EP | disclosed |
| US-4663313-A | N6 -tricyclic adenosines for treating hypertension | WARNER-LAMBERT COMPANY (US) | 1987-05-05 | — | — | US | disclosed |
| US-4593019-A | Therapy for psychosis | WARNER-LAMBERT COMPANY (US) | 1986-06-03 | — | — | US | disclosed |
| EP-0179630-A2 | N6-acenaphthyl adenosines and analogs thereof | WARNER-LAMBERT COMPANY (US) | 1986-04-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120009251-A1 | CHOLESTANOL DERIVATIVE FOR COMBINED USE | ALG1, FUT5, ALG8 | PNMT 4080/4885DRD2 4016/4885DRD4 3940/4885 |
| US-20130101679-A1 | CHOLESTANOL DERIVATIVE FOR COMBINED USE | ALG1, FUT5, ALG8 | PNMT 4080/4885DRD2 4016/4885DRD4 3940/4885 |
| US-20120015025-A1 | CHOLESTANOL DERIVATIVE FOR COMBINED USE | ALG1, FUT5, ALG8 | PNMT 4080/4885DRD2 4016/4885DRD4 3940/4885 |
| US-20150374730-A1 | CHOLESTANOL DERIVATIVE FOR COMBINED USE | ALG1, FUT5, ALG8 | PNMT 4080/4885DRD2 4016/4885DRD4 3940/4885 |
| US-20060193903-A1 | Glycoside-containing liposome | FUT5, FUT6, ALG1 | PNMT 3398/4885DRD2 4130/4885DRD4 4287/4885 |
| US-20140178464-A1 | CHOLESTANOL DERIVATIVE FOR COMBINED USE | ALG1, FUT5, ALG8 | PNMT 4080/4885DRD2 4016/4885DRD4 3940/4885 |
| US-20100062053-A1 | CHOLESTANOL DERIVATIVE FOR COMBINED USE | ALG1, FUT5, ALG8 | PNMT 4080/4885DRD2 4016/4885DRD4 3940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.