SCHEMBL2233666

SCHEMBL2233666

NC(=O)c1ncc(N)[nH]1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Carbamic Acid SCHEMBL2268424 0.83 GABRP (0.35)
SCHEMBL27938032 0.77
SCHEMBL8308592 0.77 MAP2K1 (0.38)
SCHEMBL279674 0.76
SCHEMBL30190024 0.74 PIN1 (0.47)
SCHEMBL31263227 0.72 CSF1R (0.42)
SCHEMBL4372514 0.72 DAO (0.40)
SCHEMBL24898305 0.71 ALDH1A1 (0.53)
SCHEMBL7785716 0.71 HDAC1 (0.31)
SCHEMBL3806313 0.71 HRH1 (0.50)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1178796-A4 SALTS OF AMINOIMIDAZOLE CARBOXAMIDE USEFUL IN THE PREVENTION AND TREATMENT OF LIVER DISEASES SAVVIPHARM INC (US) 2004-07-14 EP claimed
JP-2003526624-A 2003-09-09 JP claimed
EP-1178796-A1 SALTS OF AMINOIMIDAZOLE CARBOXAMIDE USEFUL IN THE PREVENTION AND TREATMENT OF LIVER DISEASES Savvipharm Inc. (US) 2002-02-13 EP claimed
US-6184227-B1 ADMINISTERING A DETOXIFYING DOSAGE TO PATIENT TO PREVENT TISSUE DAMAGE BY ALCOHOLIC BEVERAGES, REACTIVE DRUG METABOLITES OR DIETARY TOXINS SAVVIPHARM INC. 2001-02-06 US claimed
WO-2000078311-A1 SALTS OF AMINOIMIDAZOLE CARBOXAMIDE USEFUL IN THE PREVENTION AND TREATMENT OF LIVER DISEASES SAVVIPHARM INC. (US) 2000-12-28 WO claimed
CN-109952380-B Method for producing target substance 味之素株式会社 2023-07-14 CN disclosed
CN-109937257-B Method for producing target substance 味之素株式会社 2023-06-30 CN disclosed
US-9487763-B2 Nonribosomal peptide synthetases REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2016-11-08 US disclosed
US-20150361470-A1 NONRIBOSOMAL PEPTIDE SYNTHETASES THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2015-12-17 US disclosed
CN-103619332-A Acadesine derivatives, products and compositions including same, therapeutic uses thereof, and methods for synthesizing same UNIV NICE SOPHIA ANTIPOLIS 2014-03-05 CN disclosed
US-20130131072-A1 Methods for Optimizing Clinical Responsiveness to Methotrexate Therapy Using Metabolite Profiling and Pharmacogenetics PROMETHEUS LABORATORIES INC. 2013-05-23 US disclosed
US-8288158-B2 Stem cells modified to facilitate threonine catabolism BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2012-10-16 US disclosed
WO-2000078311-A1 SALTS OF AMINOIMIDAZOLE CARBOXAMIDE USEFUL IN THE PREVENTION AND TREATMENT OF LIVER DISEASES SAVVIPHARM INC. (US) 2000-12-28 WO disclosed
US-5912346-A Treatment and prevention of neoplasms with salts of aminoimidazole carboxamide and 5-amino or substituted amino 1,2,3-triazoles CONSTANTIA GRUPPE (AT) 1999-06-15 US disclosed
US-5861396-A CARDIOVASCULAR DISORDERS AND UROGENITAL SYSTEMS BAYER AKTIENGESELLSCHAFT (DE) 1999-01-19 US disclosed
US-5861406-A ANTICARCINOGENIC AGENTS AND ANTITUMOR AGENTS CONSTANTIA GRUPPE (AT) 1999-01-19 US disclosed
EP-0840608-A1 TREATMENT AND PREVENTION OF NEOPLASMS WITH SALTS OF AMINOIMIDAZOLE CARBOXAMIDE AND 5-AMINO OR SUBSTITUTED AMINO 1,2,3-TRIAZOLES Constantia Gruppe (AT) 1998-05-13 EP disclosed
US-5728707-A Treatment and prevention of primary and metastatic neoplasms with salts of aminoimidazole carboxamide CONSTANTIA GRUPPE (AT) 1998-03-17 US disclosed
EP-0771799-A1 Purin-6-one derivatives BAYER AG (DE) 1997-05-07 EP disclosed
WO-1997003668-A1 TREATMENT AND PREVENTION OF NEOPLASMS WITH SALTS OF AMINOIMIDAZOLE CARBOXAMIDE AND 5-AMINO OR SUBSTITUTED AMINO 1,2,3-TRIAZOLES CONSTANTIA GRUPPE (AT) 1997-02-06 WO disclosed