Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.50 |
| ▸ | RELA | Q04206 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL223370 | 1.00 | POLB (0.51) | POLBAPEX1HTTTDP1NPC1 | |
| SCHEMBL1531902 | 0.96 | POLB (0.47) | POLBAPEX1HTTTDP1NPC1 | |
| SCHEMBL12768417 | 0.96 | POLB (0.47) | POLBAPEX1HTTTDP1NPC1 | |
| SCHEMBL1531939 | 0.96 | POLB (0.47) | POLBAPEX1HTTTDP1NPC1 | |
| SCHEMBL1927971 | 0.96 | POLB (0.47) | POLBAPEX1HTTTDP1NPC1 | |
| SCHEMBL13531287 | 0.96 | POLB (0.47) | POLBAPEX1HTTTDP1NPC1 | |
| SCHEMBL1927974 | 0.96 | POLB (0.47) | POLBAPEX1HTTTDP1NPC1 | |
| SCHEMBL1531815 | 0.96 | POLB (0.47) | POLBAPEX1HTTTDP1NPC1 | |
| SCHEMBL1531840 | 0.96 | POLB (0.47) | POLBAPEX1HTTTDP1NPC1 | |
| SCHEMBL1532003 | 0.96 | POLB (0.47) | POLBAPEX1HTTTDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3621958-B9 | PHOTOCHROMIC INDENO FUSED PHENANTHRENOPYRAN COMPOUNDS | TRANSITIONS OPTICAL LTD (IE) | 2024-09-25 | — | — | EP | disclosed |
| EP-3621958-B1 | PHOTOCHROMIC INDENO FUSED PHENANTHRENOPYRAN COMPOUNDS | TRANSITIONS OPTICAL LTD (IE) | 2024-07-10 | — | — | EP | disclosed |
| EP-2718755-B1 | POLARIZING PHOTOCHROMIC ARTICLES | TRANSITIONS OPTICAL INC (US) | 2024-05-29 | — | — | EP | disclosed |
| EP-2718754-B1 | POLARIZING PHOTOCHROMIC ARTICLES | TRANSITIONS OPTICAL INC (US) | 2024-01-24 | — | — | EP | disclosed |
| EP-3698209-B1 | DISPLAY DEVICES INCLUDING PHOTOCHROMIC-DICHROIC COMPOUNDS AND DICHROIC COMPOUNDS | PPG IND OHIO INC (US) | 2023-06-07 | — | — | EP | disclosed |
| US-10866455-B2 | Display devices including photochromic-dichroic compounds and dichroic compounds | PPG INDUSTRIES OHIO, INC. (US) | 2020-12-15 | — | — | US | disclosed |
| US-20200048216-A1 | Photochromic Indeno Fused Phenanthrenopyran Compounds | TRANSITIONS OPTICAL, LTD. (IE) | 2020-02-13 | — | — | US | disclosed |
| US-20190121196-A1 | DISPLAY DEVICES INCLUDING PHOTOCHROMIC-DICHROIC COMPOUNDS AND DICHROIC COMPOUNDS | PPG INDUSTRIES OHIO, INC. (US) | 2019-04-25 | — | — | US | disclosed |
| US-8623238-B2 | Mesogenic stabilizers | TRANSITIONS OPTICAL, INC. (US) | 2014-01-07 | — | — | US | disclosed |
| US-8613868-B2 | Mesogenic stabilizers | TRANSITIONS OPTICAL, INC (US) | 2013-12-24 | — | — | US | disclosed |
| US-8545015-B2 | Polarizing photochromic articles | TRANSITIONS OPTICAL, INC. (US) | 2013-10-01 | — | — | US | disclosed |
| US-8431039-B2 | Mesogenic stabilizers | TRANSITIONS OPTICAL, INC. (US) | 2013-04-30 | — | — | US | disclosed |
| WO-2013022610-A1 | MESOGENIC STABILIZERS | TRANSITIONS OPTICAL, INC. (US) | 2013-02-14 | — | — | WO | disclosed |
| WO-2013022605-A1 | MESOGENIC STABILIZERS | TRANSITIONS OPTICAL, INC. (US) | 2013-02-14 | — | — | WO | disclosed |
| US-8349210-B2 | Mesogenic stabilizers | TRANSITIONS OPTICAL, INC. (US) | 2013-01-08 | — | — | US | disclosed |
| US-20120120473-A1 | POLARIZING PHOTOCHROMIC ARTICLES | TRANSITIONS OPTICAL, INC. (US) | 2012-05-17 | — | — | US | disclosed |
| US-20120027960-A1 | MESOGENIC STABILIZERS | TRANSITIONS OPTICAL, INC. (US) | 2012-02-02 | — | — | US | disclosed |
| US-20120021144-A1 | MESOGENIC STABILIZERS | TRANSITIONS OPTICAL, INC. (US) | 2012-01-26 | — | — | US | disclosed |
| US-20120002141-A1 | MESOGENIC STABILIZERS | TRANSITIONS OPTICAL, INC. (US) | 2012-01-05 | — | — | US | disclosed |
| US-20120003401-A1 | MESOGENIC STABILIZERS | TRANSITIONS OPTICAL, INC. (US) | 2012-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048216-A1 | Photochromic Indeno Fused Phenanthrenopyran Compounds | ALDH1A2, RB1, INCENP | POLB 2696/4885APEX1 758/4885HTT 92/4885 |
| US-20120021144-A1 | MESOGENIC STABILIZERS | C1S, C5, CCNL2 | POLB 3936/4885APEX1 3083/4885HTT 1333/4885 |
| US-20120027960-A1 | MESOGENIC STABILIZERS | C1S, PYM1, H1-0 | POLB 3193/4885APEX1 2337/4885HTT 1025/4885 |
| US-20120003401-A1 | MESOGENIC STABILIZERS | PYM1, BMI1, C1S | POLB 3120/4885APEX1 1823/4885HTT 823/4885 |
| US-20120002141-A1 | MESOGENIC STABILIZERS | BMI1, METTL14, PYM1 | POLB 4052/4885APEX1 2460/4885HTT 743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.