SCHEMBL22338451

SCHEMBL22338451

COc1ccc(-c2sc(NC(=O)C(C)(C)C)nc2C)cc1S(=O)(=O)NC(C)C

nearest known ligand 0.74

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 5/20 0.74
PIK3C2G O75747 5/20 0.73
PIK3CG P48736 4/20 0.73
PIK3CA P42336 2/20 0.73
PI4KB Q9UBF8 12/20 0.69
PI4KA P42356 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14851733 0.90 PIK3CD (0.73) PIK3CDPIK3C2GPIK3CGPIK3CAPI4KB
SCHEMBL24535632 0.89 PIK3CD (0.78) PIK3CDPIK3C2GPIK3CGPIK3CAPI4KB
SCHEMBL22336672 0.86 PIK3CD (0.83) PIK3CDPIK3C2GPIK3CGPIK3CAPI4KB
SCHEMBL22336563 0.86 PI4KB (0.74) PIK3CDPIK3C2GPIK3CGPIK3CAPI4KB
SCHEMBL14851953 0.86 PIK3C2G (0.75) PIK3CDPIK3C2GPIK3CGPIK3CAPI4KB
SCHEMBL22338311 0.86 PIK3CD (0.82) PIK3CDPIK3C2GPIK3CGPIK3CAPI4KB
SCHEMBL22336531 0.85 PIK3CD (0.85) PIK3CDPIK3C2GPIK3CGPIK3CAPI4KB
SCHEMBL14851574 0.84 PIK3CD (1.00) PIK3CDPIK3C2GPIK3CGPIK3CAPI4KB
SCHEMBL24535575 0.84 PIK3CD (0.86) PIK3CDPIK3C2GPIK3CGPIK3CAPI4KB
SCHEMBL29420845 0.84 PIK3CD (1.00) PIK3CDPIK3C2GPIK3CGPIK3CAPI4KB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230063768-A1 IMMUNOPHILIN BINDING AGENTS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2023-03-02 US disclosed
US-20220193242-A1 IMMUNOPHILIN-DEPENDENT INHIBITORS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2022-06-23 US disclosed
WO-2020163594-A1 IMMUNOPHILIN BINDING AGENTS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2020-08-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220193242-A1 IMMUNOPHILIN-DEPENDENT INHIBITORS AND USES THEREOF CD74, CD2BP2, SERPINB1 PIK3CD 3580/4885PIK3C2G 3600/4885PIK3CG 3212/4885
US-20230063768-A1 IMMUNOPHILIN BINDING AGENTS AND USES THEREOF PMP22, MAG, FABP7 PIK3CD 4766/4885PIK3C2G 4504/4885PIK3CG 4534/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.