Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 12/20 | 1.00 |
| ▸ | CA12 | O43570 | 4/20 | 1.00 |
| ▸ | CA9 | Q16790 | 4/20 | 1.00 |
| ▸ | ERCC1 | P07992 | 2/20 | 1.00 |
| ▸ | ERCC4 | Q92889 | 2/20 | 1.00 |
| ▸ | RNASEH1 | O60930 | 1/20 | 1.00 |
| ▸ | ERCC5 | P28715 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.61 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.61 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.61 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.61 |
| ▸ | DAO | P14920 | 1/20 | 0.60 |
| ▸ | DNASE1 | P24855 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1520708 | 1.00 | FEN1 (1.00) | FEN1CA12CA9ERCC1ERCC4 | |
| SCHEMBL24754440 | 0.81 | CA12 (0.68) | FEN1CA12CA9ERCC1ERCC4 | |
| SCHEMBL29959916 | 0.78 | FEN1 (1.00) | FEN1CA12CA9ERCC1ERCC4 | |
| SCHEMBL18670498 | 0.78 | FEN1 (1.00) | FEN1CA12CA9ERCC1ERCC4 | |
| SCHEMBL3754362 | 0.76 | ALDH1A1 (1.00) | FEN1CA12CA9ERCC1ERCC4 | |
| SCHEMBL430775 | 0.76 | ADORA3 (1.00) | FEN1CA12CA9ERCC1ERCC4 | |
| SCHEMBL29897963 | 0.76 | ADORA3 (1.00) | FEN1CA12CA9ERCC1ERCC4 | |
| SCHEMBL13947065 | 0.76 | ALDH1A1 (0.61) | FEN1CA12CA9ERCC1ERCC4 | |
| SCHEMBL19577287 | 0.76 | ALDH1A1 (0.61) | FEN1CA12CA9ERCC1ERCC4 | |
| SCHEMBL8343584 | 0.76 | ALDH1A1 (0.61) | FEN1CA12CA9ERCC1ERCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111303054-B | 3-acylamino-1, 3-quinazoline-2-ketone compound and preparation method and application thereof | 湖南科技大学 | 2023-04-07 | — | — | CN | disclosed |
| CN-108430978-B | 3-hydroxy-quinazoline-2, 4-dione derivatives and their use as nuclease modulators | 路德维格癌症研究所有限责任公司 | 2022-11-22 | — | — | CN | disclosed |
| CN-108430978-B | 3-hydroxy-quinazoline-2, 4-dione derivatives and their use as nuclease modulators | 路德维格癌症研究所有限责任公司 | 2022-11-22 | — | — | CN | disclosed |
| EP-3353154-B3 | 3-HYDROXY-7-(SULFONYL)QUINAZOLINE-2,4(1H,3H)-DIONE AND 3-HYDROXY-PYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE DERIVATIVES AND RELATED COMPOUNDS AS FLAP-ENDONUCLEASE 1 (FEN-1) INHIBITORS FOR USE IN CANCER THERAPY | LUDWIG INST FOR CANCER RES LTD (CH) | 2022-10-19 | — | — | EP | disclosed |