Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 15/20 | 0.63 |
| ▸ | TSLP | Q969D9 | 3/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22342189 | 0.97 | KEAP1 (0.60) | KEAP1TSLPPLAU | |
| SCHEMBL22342178 | 0.95 | KEAP1 (0.61) | KEAP1TSLPPLAU | |
| SCHEMBL22342188 | 0.94 | KEAP1 (0.57) | KEAP1TSLPPLAU | |
| SCHEMBL22342205 | 0.93 | KEAP1 (0.62) | KEAP1TSLP | |
| SCHEMBL22342206 | 0.93 | KEAP1 (0.62) | KEAP1TSLP | |
| SCHEMBL22342209 | 0.92 | KEAP1 (0.59) | KEAP1TSLPPLAU | |
| SCHEMBL22341357 | 0.92 | KEAP1 (0.58) | KEAP1TSLP | |
| SCHEMBL22341326 | 0.91 | KEAP1 (0.60) | KEAP1TSLPPLAU | |
| SCHEMBL22342263 | 0.88 | KEAP1 (0.63) | KEAP1TSLP | |
| SCHEMBL22342185 | 0.84 | KEAP1 (0.64) | KEAP1TSLP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200255478-A1 | NOVEL COMPOUNDS ACTIVATING THE NRF2 PATHWAY | ALMIRALL SA (ES) | 2020-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200255478-A1 | NOVEL COMPOUNDS ACTIVATING THE NRF2 PATHWAY | KEAP1, NFE2L2, HMOX1 | KEAP1 1/4885TSLP 2046/4885PLAU 3129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.