Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDC1 | Q96MU7 | 14/20 | 0.56 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5451873 | 0.87 | YTHDC1 (0.72) | YTHDC1P2RX7 | |
| SCHEMBL30898205 | 0.87 | YTHDC1 (0.72) | YTHDC1P2RX7 | |
| SCHEMBL30898278 | 0.85 | YTHDC1 (0.68) | YTHDC1P2RX7HDAC1HDAC2HDAC8 | |
| SCHEMBL183057 | 0.85 | YTHDC1 (0.68) | YTHDC1P2RX7HDAC1HDAC2HDAC8 | |
| SCHEMBL5458838 | 0.81 | YTHDC1 (0.76) | YTHDC1 | |
| SCHEMBL5471560 | 0.80 | YTHDC1 (0.55) | YTHDC1P2RX7HDAC6HDAC3HDAC4 | |
| SCHEMBL17144339 | 0.80 | ADORA2A (0.56) | YTHDC1P2RX7 | |
| SCHEMBL5465713 | 0.79 | P2RX7 (0.56) | YTHDC1P2RX7HDAC6HDAC3HDAC4 | |
| SCHEMBL12795895 | 0.78 | HDAC6 (0.56) | YTHDC1P2RX7HDAC6HDAC3HDAC4 | |
| SCHEMBL12537206 | 0.78 | YTHDC1 (0.53) | YTHDC1P2RX7HDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3924353-A1 | HETEROCYCLIC NITROGEN-CONTAINING PURINE DERIVATIVES, PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AND THEIR USE IN NEUROPROTECTION | Univerzita Palackého (CZ) | 2021-12-22 | — | — | EP | disclosed |
| WO-2020164648-A1 | HETEROCYCLIC NITROGEN-CONTAINING PURINE DERIVATIVES, PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AND THEIR USE IN NEUROPROTECTION | UNIVERZITA PALACKEHO (CZ) | 2020-08-20 | — | — | WO | disclosed |