SCHEMBL30898205

SCHEMBL30898205

Clc1cccc(Cn2cnc3c(Cl)nc(Cl)nc32)c1

nearest known ligand 0.72

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
YTHDC1 Q96MU7 11/20 0.72
ADORA2A P29274 1/20 0.55
ADORA1 P30542 1/20 0.55
P2RX7 Q99572 1/20 0.54
CNR2 P34972 4/20 0.52
ACP1 P24666 1/20 0.51
HTR6 P50406 1/20 0.51
PDE8A O60658 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5451873 1.00 YTHDC1 (0.72) YTHDC1ADORA2AADORA1P2RX7CNR2
SCHEMBL30898278 0.87 YTHDC1 (0.68) YTHDC1ADORA2AP2RX7CNR2
SCHEMBL183057 0.87 YTHDC1 (0.68) YTHDC1ADORA2AP2RX7CNR2
SCHEMBL22345236 0.87 YTHDC1 (0.56) YTHDC1P2RX7
SCHEMBL5465713 0.84 P2RX7 (0.56) YTHDC1ADORA2AP2RX7ACP1PDE8A
SCHEMBL27387505 0.84 YTHDC1 (1.00) YTHDC1
SCHEMBL5458838 0.84 YTHDC1 (0.76) YTHDC1ADORA2AADORA1PDE8A
SCHEMBL30898279 0.84 YTHDC1 (0.68) YTHDC1ADORA2AADORA1CNR2ACP1
SCHEMBL12795895 0.83 HDAC6 (0.56) YTHDC1P2RX7PDE8A
SCHEMBL5471560 0.82 YTHDC1 (0.55) YTHDC1P2RX7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024105159-A1 LIGANDS OF THE M6A-RNA READERS UNIVERSITY OF ZURICH (CH) 2024-05-23 WO disclosed