Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 5/20 | 0.36 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.34 |
| ▸ | BRD4 | O60885 | 3/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2235776 | 0.83 | MEN1 (0.37) | RIPK1ADRA2AADRA2BADRA2CCREBBP | |
| SCHEMBL17312606 | 0.82 | RIPK1 (0.44) | RIPK1CREBBPBRD4ALDH1A1 | |
| SCHEMBL17312607 | 0.82 | RIPK1 (0.44) | RIPK1CREBBPBRD4ALDH1A1 | |
| SCHEMBL3914941 | 0.76 | RIPK1 (0.46) | RIPK1RIPK3 | |
| SCHEMBL12345906 | 0.76 | RIPK1 (0.40) | RIPK1RIPK3ADRA2AADRA2BADRA2C | |
| SCHEMBL12345907 | 0.74 | CYP19A1 (0.39) | RIPK1RIPK3ADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL2234462 | 0.73 | ANPEP (0.39) | RIPK1RIPK3ADRA2AADRA2BADRA2C | |
| SCHEMBL17312421 | 0.72 | — | — | |
| SCHEMBL17312422 | 0.72 | — | — | |
| SCHEMBL17312436 | 0.71 | NR3C2 (0.40) | RIPK1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7994161-B2 | Derivatives of 2-alkoxy-3,4,5-trihydroxy-alkyl amides, preparation and use thereof, and compositions containing the same | SANOFI-AVENTIS (FR) | 2011-08-09 | — | — | US | disclosed |