Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | CCKAR | P32238 | 1/20 | 0.35 |
| ▸ | CCKBR | P32239 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 4/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2234585 | 0.83 | RIPK1 (0.36) | MEN1ALDH1A1KMT2AADRA2AADRA2B | |
| SCHEMBL17312607 | 0.82 | RIPK1 (0.44) | ALDH1A1BRD4CREBBPRIPK1 | |
| SCHEMBL17312606 | 0.82 | RIPK1 (0.44) | ALDH1A1BRD4CREBBPRIPK1 | |
| SCHEMBL3913865 | 0.76 | RIPK1 (0.46) | CCKARCCKBRTRPV1RIPK1 | |
| SCHEMBL12345899 | 0.76 | BRD4 (0.38) | MEN1ALDH1A1KMT2AHTR7DRD2 | |
| SCHEMBL2404090 | 0.76 | ALDH1A1 (0.39) | MEN1ALDH1A1KMT2ACCKARCCKBR | |
| SCHEMBL2362101 | 0.76 | ALDH1A1 (0.39) | MEN1ALDH1A1KMT2ACCKARCCKBR | |
| SCHEMBL12345900 | 0.74 | ADRA2A (0.38) | MEN1ALDH1A1KMT2AHTR7DRD2 | |
| SCHEMBL17312584 | 0.73 | RIPK1 (0.39) | MEN1ALDH1A1KMT2ACREBBPRIPK1 | |
| SCHEMBL17312583 | 0.73 | RIPK1 (0.39) | MEN1ALDH1A1KMT2ACREBBPRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7994161-B2 | Derivatives of 2-alkoxy-3,4,5-trihydroxy-alkyl amides, preparation and use thereof, and compositions containing the same | SANOFI-AVENTIS (FR) | 2011-08-09 | — | — | US | disclosed |