Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53BP1 | Q12888 | 4/20 | 0.85 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.53 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KAT6A | Q92794 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12305721 | 0.83 | TP53BP1 (0.64) | TP53BP1PSMB8PSMB5KMT2AGAA | |
| SCHEMBL21345718 | 0.82 | TP53BP1 (0.67) | TP53BP1PSMB8PSMB5KMT2AGAA | |
| SCHEMBL104557 | 0.82 | TP53BP1 (0.67) | TP53BP1PSMB8PSMB5KMT2AGAA | |
| SCHEMBL30277616 | 0.82 | TP53BP1 (0.67) | TP53BP1PSMB8PSMB5KMT2AGAA | |
| SCHEMBL21972887 | 0.81 | NPC1 (0.61) | TP53BP1KMT2AGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL11994348 | 0.81 | TP53BP1 (0.65) | TP53BP1PSMB8PSMB5KMT2AGAA | |
| SCHEMBL20646759 | 0.80 | TP53BP1 (0.64) | TP53BP1KMT2AGAAHSD17B10SMN1; SMN2 | |
| SCHEMBL19767696 | 0.80 | TP53BP1 (0.67) | TP53BP1KMT2ASMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL21097734 | 0.79 | TP53BP1 (0.62) | TP53BP1PSMB8PSMB5KMT2ASMN1; SMN2 | |
| SCHEMBL30277542 | 0.79 | TP53BP1 (0.62) | TP53BP1KMT2AGAAHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10744205-B2 | Antibody drug conjugates of kinesin spindel protein (KSP) inhibitors with anti-CD123-antibodies | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2020-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10744205-B2 | Antibody drug conjugates of kinesin spindel protein (KSP) inhibitors with anti-CD123-antibodies | KIF23, KIF2C, KIF18A | TP53BP1 3622/4885PSMB8 2891/4885PSMB5 2996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.