Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.54 |
| ▸ | CTSS | P25774 | 4/20 | 0.51 |
| ▸ | KLK7 | P49862 | 4/20 | 0.49 |
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.49 |
| ▸ | PPARG | P37231 | 2/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 5/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | TLR2 | O60603 | 1/20 | 0.46 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22355228 | 1.00 | PPARA (0.54) | PPARACTSSKLK7KLK5PPARG | |
| SCHEMBL22355211 | 0.91 | CTSK (0.51) | PPARACTSSSYKCTSKCTSL | |
| SCHEMBL3817109 | 0.91 | PPARA (0.55) | PPARACTSSKLK7KLK5PPARG | |
| SCHEMBL1517760 | 0.91 | PPARA (0.55) | PPARACTSSKLK7KLK5PPARG | |
| SCHEMBL2011835 | 0.91 | PPARA (0.55) | PPARACTSSKLK7KLK5PPARG | |
| SCHEMBL13007476 | 0.91 | PPARA (0.55) | PPARACTSSKLK7KLK5PPARG | |
| SCHEMBL27905048 | 0.90 | PPARA (0.53) | PPARACTSSKLK7KLK5PPARG | |
| SCHEMBL10587650 | 0.90 | KLK7 (0.54) | PPARACTSSKLK7KLK5PPARG | |
| SCHEMBL2301376 | 0.90 | PPARA (0.54) | PPARACTSSKLK7KLK5PPARG | |
| SCHEMBL19020373 | 0.90 | PPARA (0.54) | PPARACTSSKLK7KLK5PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12240797-B2 | Method of preparing a DON prodrug from L-glutamic acid | DRACEN PHARMACEUTICALS, INC. (US) | 2025-03-04 | — | — | US | disclosed |
| US-20220089522-A1 | METHOD OF PREPARING A DON PRODRUG FROM L-GLUTAMIC ACID | DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C), AS COLLATERAL AGENT | 2022-03-24 | — | — | US | disclosed |
| WO-2020167831-A1 | METHOD OF PREPARING A DON PRODRUG FROM L-GLUTAMIC ACID | DRACEN PHARMACEUTICALS, INC. (US) | 2020-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220089522-A1 | METHOD OF PREPARING A DON PRODRUG FROM L-GLUTAMIC ACID | GLUL, GLRA1, GRIN1 | PPARA 2196/4885CTSS 3858/4885KLK7 3602/4885 |
| US-12240797-B2 | Method of preparing a DON prodrug from L-glutamic acid | GLUL, GLRA1, GLS | PPARA 2058/4885CTSS 3765/4885KLK7 3498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.