Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22355685 | 0.82 | ROCK2 (0.50) | ROCK2 | |
| SCHEMBL21503717 | 0.80 | ROCK2 (0.37) | ROCK2 | |
| SCHEMBL22355724 | 0.80 | ROCK2 (0.47) | ROCK2 | |
| SCHEMBL22355760 | 0.78 | ROCK2 (0.47) | ROCK2 | |
| SCHEMBL24743232 | 0.78 | KCNJ1 (0.33) | — | |
| SCHEMBL22355670 | 0.77 | OTUD7B (0.32) | — | |
| SCHEMBL22355680 | 0.75 | BACE1 (0.33) | — | |
| SCHEMBL21490331 | 0.75 | ROCK2 (0.56) | ROCK2 | |
| SCHEMBL29442942 | 0.75 | ROCK2 (0.56) | ROCK2 | |
| SCHEMBL24743781 | 0.72 | USP30 (0.40) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3481817-B1 | SPIROLACTAMS AS INHIBITORS OF ROCK | BRISTOL MYERS SQUIBB CO (US) | 2020-08-19 | — | — | EP | disclosed |