Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aripiprazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 20/20 | 0.92 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.92 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.92 |
| ▸ | DRD3 | P35462 | 9/20 | 0.92 |
| ▸ | DRD4 | P21917 | 8/20 | 0.92 |
| ▸ | DRD1 | P21728 | 2/20 | 0.92 |
| ▸ | DRD5 | P21918 | 2/20 | 0.92 |
| ▸ | HTR2C | P28335 | 2/20 | 0.92 |
| ▸ | HTR2B | P41595 | 2/20 | 0.92 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.92 |
| ▸ | MEN1 | O00255 | 1/20 | 0.92 |
| ▸ | MLNR | O43193 | 1/20 | 0.92 |
| ▸ | HTR3B | O95264 | 1/20 | 0.92 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.92 |
| ▸ | ESR1 | P03372 | 1/20 | 0.92 |
| ▸ | PGR | P06401 | 1/20 | 0.92 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.92 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.92 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.92 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.92 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aripiprazole SCHEMBL2080933 | 0.97 | DRD2 (0.95) | DRD2DRD3DRD4HTR1ADRD1 | |
| Aripiprazole SCHEMBL982189 | 0.96 | DRD2 (1.00) | DRD2DRD3DRD4HTR1ADRD1 | |
| Aripiprazole SCHEMBL29475637 | 0.96 | DRD2 (1.00) | DRD2DRD3DRD4HTR1ADRD1 | |
| Aripiprazole SCHEMBL8255 | 0.96 | DRD2 (1.00) | DRD2DRD3DRD4HTR1ADRD1 | |
| Aripiprazole SCHEMBL29475638 | 0.96 | DRD2 (1.00) | DRD2DRD3DRD4HTR1ADRD1 | |
| Aripiprazole SCHEMBL29438823 | 0.96 | DRD2 (1.00) | DRD2DRD3DRD4HTR1ADRD1 | |
| Aripiprazole SCHEMBL29356997 | 0.96 | DRD2 (1.00) | DRD2DRD3DRD4HTR1ADRD1 | |
| Aripiprazole SCHEMBL6023131 | 0.95 | DRD2 (0.92) | DRD2DRD3DRD4HTR1ADRD1 | |
| Aripiprazole SCHEMBL7097505 | 0.95 | DRD2 (0.98) | DRD2DRD3DRD4HTR1ADRD1 | |
| Aripiprazole SCHEMBL31174198 | 0.95 | DRD2 (0.98) | DRD2DRD3DRD4HTR1ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105085397-B | The ethanolates novel crystal forms of Aripiprazole half, preparation method and the usage | 上海特化医药科技有限公司 | 2018-02-09 | — | — | CN | claimed |
| CN-105085397-A | Aripiprazole semi-ethanolate with new crystal form, and preparation method and use thereof | TOPHARMAN SHANGHAI CO LTD | 2015-11-25 | — | — | CN | claimed |
| CN-103172563-B | Industrialized preparation of small-particle-size crystal-form I aripiprazole | JEWIM PHARMACEUTICAL RES INST CO LTD | 2015-03-25 | — | — | CN | claimed |
| EP-2093217-B1 | Process for preparing Form X of aripiprazole | SANDOZ AG (CH) | 2014-03-12 | — | — | EP | claimed |
| CN-103172563-A | Industrialized preparation of small-particle-size crystal-form I aripiprazole | JEWIM BEIJING PHARMACEUTICAL INST CO LTD | 2013-06-26 | — | — | CN | claimed |
| CN-101370780-B | polymorphic forms of aripiprazole | SANDOZ AG | 2012-05-16 | — | — | CN | claimed |
| US-8008490-B2 | novel polymorphic forms of aripiprazole in the treatment of schizophrenia; properties suitable for pharmaceutical processing on a commercial scale | SANDOZ AG (CH) | 2011-08-30 | — | — | US | claimed |
| EP-2093217-A1 | Polymorph and solvates of aripiprazole | Sandoz AG (CH) | 2009-08-26 | — | — | EP | claimed |
| CN-101370780-A | Organic compounds | SANDOZ AG (CH) | 2009-02-18 | — | — | CN | claimed |
| US-20080132518-A1 | Organic Compounds | SANDOZ AG (CH) | 2008-06-05 | — | — | US | claimed |
| EP-1844016-A1 | POLYMORPH AND SOLVATES OF ARIPIPRAZOLE | Sandoz AG (CH) | 2007-10-17 | — | — | EP | claimed |
| WO-2006079548-A1 | ORGANIC COMPOUNDS | SANDOZ AG (CH) | 2006-08-03 | — | — | WO | claimed |
| EP-1686117-A1 | Polymorph and solvates of aripiprazole | Sandoz AG (CH) | 2006-08-02 | — | — | EP | claimed |
| CN-105085397-B | The ethanolates novel crystal forms of Aripiprazole half, preparation method and the usage | 上海特化医药科技有限公司 | 2018-02-09 | — | — | CN | disclosed |
| CN-105085397-A | Aripiprazole semi-ethanolate with new crystal form, and preparation method and use thereof | TOPHARMAN SHANGHAI CO LTD | 2015-11-25 | — | — | CN | disclosed |
| CN-103172563-B | Industrialized preparation of small-particle-size crystal-form I aripiprazole | JEWIM PHARMACEUTICAL RES INST CO LTD | 2015-03-25 | — | — | CN | disclosed |
| EP-1686117-A1 | Polymorph and solvates of aripiprazole | Sandoz AG (CH) | 2006-08-02 | — | — | EP | disclosed |
| WO-2006077584-A2 | NEW CRYSTALLINE FORMS OF ARIPIPRAZOLE | CHEMAGIS LTD. (IL) | 2006-07-27 | — | — | WO | disclosed |
| WO-2006030446-A1 | PROCESS FOR THE PREPARATION OF POLYMORPHS, SOLVATES OF ARIPIPRAZOLE USING ARIPIPRAZOLE ACID SALTS | MATRIX LABORATORIES LTD (IN) | 2006-03-23 | — | — | WO | disclosed |
| CN-1676517-A | Aripiprazole crystal form | DEZHONG WANQUAN MEDICINE TECHN (CN) | 2005-10-05 | — | — | CN | disclosed |