Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aripiprazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 20/20 | 0.95 |
| ▸ | HTR1A known ✓ | P08908 | 3/20 | 0.95 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.95 |
| ▸ | DRD3 | P35462 | 7/20 | 0.95 |
| ▸ | DRD4 | P21917 | 6/20 | 0.95 |
| ▸ | HTR2B | P41595 | 3/20 | 0.95 |
| ▸ | DRD1 | P21728 | 2/20 | 0.95 |
| ▸ | DRD5 | P21918 | 2/20 | 0.95 |
| ▸ | HTR2C | P28335 | 2/20 | 0.95 |
| ▸ | HTR7 | P34969 | 2/20 | 0.95 |
| ▸ | HTR6 | P50406 | 2/20 | 0.95 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.95 |
| ▸ | MEN1 | O00255 | 1/20 | 0.95 |
| ▸ | MLNR | O43193 | 1/20 | 0.95 |
| ▸ | HTR3B | O95264 | 1/20 | 0.95 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.95 |
| ▸ | ESR1 | P03372 | 1/20 | 0.95 |
| ▸ | PGR | P06401 | 1/20 | 0.95 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.95 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.95 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aripiprazole SCHEMBL8255 | 0.97 | DRD2 (1.00) | DRD2DRD3DRD4HTR1AHTR2A | |
| Aripiprazole SCHEMBL29356997 | 0.97 | DRD2 (1.00) | DRD2DRD3DRD4HTR1AHTR2A | |
| Aripiprazole SCHEMBL29438823 | 0.97 | DRD2 (1.00) | DRD2DRD3DRD4HTR1AHTR2A | |
| Aripiprazole SCHEMBL29475638 | 0.97 | DRD2 (1.00) | DRD2DRD3DRD4HTR1AHTR2A | |
| Aripiprazole SCHEMBL29475637 | 0.97 | DRD2 (1.00) | DRD2DRD3DRD4HTR1AHTR2A | |
| Aripiprazole SCHEMBL982189 | 0.97 | DRD2 (1.00) | DRD2DRD3DRD4HTR1AHTR2A | |
| Aripiprazole SCHEMBL6023131 | 0.97 | DRD2 (0.92) | DRD2DRD3DRD4HTR1AHTR2A | |
| Aripiprazole SCHEMBL2235757 | 0.97 | DRD2 (0.92) | DRD2DRD3DRD4HTR1AHTR2A | |
| Aripiprazole SCHEMBL7097505 | 0.96 | DRD2 (0.98) | DRD2DRD3DRD4HTR1AHTR2A | |
| Aripiprazole SCHEMBL30958765 | 0.96 | DRD2 (0.98) | DRD2DRD3DRD4HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2093217-B1 | Process for preparing Form X of aripiprazole | SANDOZ AG (CH) | 2014-03-12 | — | — | EP | claimed |
| CN-101370780-B | polymorphic forms of aripiprazole | SANDOZ AG | 2012-05-16 | — | — | CN | claimed |
| US-8008490-B2 | novel polymorphic forms of aripiprazole in the treatment of schizophrenia; properties suitable for pharmaceutical processing on a commercial scale | SANDOZ AG (CH) | 2011-08-30 | — | — | US | claimed |
| EP-2093217-A1 | Polymorph and solvates of aripiprazole | Sandoz AG (CH) | 2009-08-26 | — | — | EP | claimed |
| US-20090198059-A1 | Process for the preparation of polymorphs, solvates of aripiprazole using aripirazole acid salts | SATYANARAYANA CHAVA | 2009-08-06 | — | — | US | claimed |
| CN-101370780-A | Organic compounds | SANDOZ AG (CH) | 2009-02-18 | — | — | CN | claimed |
| US-20080132518-A1 | Organic Compounds | SANDOZ AG (CH) | 2008-06-05 | — | — | US | claimed |
| EP-1844016-A1 | POLYMORPH AND SOLVATES OF ARIPIPRAZOLE | Sandoz AG (CH) | 2007-10-17 | — | — | EP | claimed |
| EP-1797039-A1 | PROCESS FOR THE PREPARATION OF POLYMORPHS, SOLVATES OF ARIPIPRAZOLE USING ARIPIPRAZOLE ACID SALTS | Matrix Laboratories Ltd (IN) | 2007-06-20 | — | — | EP | claimed |
| WO-2006079548-A1 | ORGANIC COMPOUNDS | SANDOZ AG (CH) | 2006-08-03 | — | — | WO | claimed |
| EP-1686117-A1 | Polymorph and solvates of aripiprazole | Sandoz AG (CH) | 2006-08-02 | — | — | EP | claimed |
| WO-2006030446-A1 | PROCESS FOR THE PREPARATION OF POLYMORPHS, SOLVATES OF ARIPIPRAZOLE USING ARIPIPRAZOLE ACID SALTS | MATRIX LABORATORIES LTD (IN) | 2006-03-23 | — | — | WO | claimed |
| CN-1676517-A | Aripiprazole crystal form | DEZHONG WANQUAN MEDICINE TECHN (CN) | 2005-10-05 | — | — | CN | claimed |
| CN-103172563-B | Industrialized preparation of small-particle-size crystal-form I aripiprazole | JEWIM PHARMACEUTICAL RES INST CO LTD | 2015-03-25 | — | — | CN | disclosed |
| EP-2093217-B1 | Process for preparing Form X of aripiprazole | SANDOZ AG (CH) | 2014-03-12 | — | — | EP | disclosed |
| CN-103172563-A | Industrialized preparation of small-particle-size crystal-form I aripiprazole | JEWIM BEIJING PHARMACEUTICAL INST CO LTD | 2013-06-26 | — | — | CN | disclosed |
| EP-1686117-A1 | Polymorph and solvates of aripiprazole | Sandoz AG (CH) | 2006-08-02 | — | — | EP | disclosed |
| US-20060142299-A1 | Crystalline aripiprazole solvates | SYNTHON BV (NL) | 2006-06-29 | — | — | US | disclosed |
| WO-2006053780-A1 | CRYSTALLINE ARIPIPRAZOLE SOLVATES | SYNTHON B.V. (NL) | 2006-05-26 | — | — | WO | disclosed |
| WO-2006030446-A1 | PROCESS FOR THE PREPARATION OF POLYMORPHS, SOLVATES OF ARIPIPRAZOLE USING ARIPIPRAZOLE ACID SALTS | MATRIX LABORATORIES LTD (IN) | 2006-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142299-A1 | Crystalline aripiprazole solvates | ADH1A, ADH5, ADH1C | DRD2 760/4885HTR1A 148/4885HTR2A 146/4885 |
| US-20090198059-A1 | Process for the preparation of polymorphs, solvates of aripiprazole using aripirazole acid salts | CYP3A4, CYP3A5, CYP3A43 | DRD2 1058/4885HTR1A 291/4885HTR2A 753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.