SCHEMBL22357680

SCHEMBL22357680

COc1cc(B2OC(C)(C)C(C)(C)O2)cc2c1NC(O)C2

nearest known ligand 0.32

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
CSF1R P07333 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22357671 0.82 ROCK1 (0.37)
SCHEMBL28660659 0.75 CSF1R (0.33) CSF1R
SCHEMBL18189286 0.74 CSF1R (0.37) CSF1R
SCHEMBL20600668 0.71 CA1 (0.40) CSF1R
SCHEMBL22726982 0.69 CSF1R (0.43) CSF1R
SCHEMBL2278746 0.69 ACHE (0.43) CSF1R
SCHEMBL19099105 0.68 MEN1 (0.38) CSF1R
SCHEMBL22491172 0.68 CSF1R (0.37) CSF1R
SCHEMBL19869866 0.67 BRD4 (0.46) CSF1R
SCHEMBL20562111 0.66 CA1 (0.44) CSF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3532476-B1 FUSED AZAHETEROCYCLIC COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2020-08-19 EP disclosed