Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 18/20 | 0.53 |
| ▸ | JAK3 | P52333 | 13/20 | 0.53 |
| ▸ | LCK | P06239 | 9/20 | 0.52 |
| ▸ | EGFR | P00533 | 6/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22346053 | 0.79 | BTK (0.74) | BTKJAK3LCKEGFR | |
| SCHEMBL22358871 | 0.79 | BTK (0.74) | BTKJAK3LCKEGFR | |
| SCHEMBL22346874 | 0.79 | BTK (0.74) | BTKJAK3LCKEGFR | |
| SCHEMBL22346882 | 0.75 | BTK (0.64) | BTKJAK3LCKEGFR | |
| SCHEMBL29871745 | 0.75 | BTK (0.64) | BTKJAK3LCKEGFR | |
| SCHEMBL22346873 | 0.75 | BTK (0.64) | BTKJAK3LCKEGFR | |
| SCHEMBL18296430 | 0.75 | BTK (0.64) | BTKJAK3LCKEGFR | |
| SCHEMBL18296292 | 0.75 | BTK (0.55) | BTKJAK3LCKEGFR | |
| SCHEMBL25607781 | 0.74 | BTK (0.49) | BTKJAK3LCKEGFR | |
| SCHEMBL18283479 | 0.73 | BTK (0.74) | BTKJAK3LCKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020167518-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2020-08-20 | — | — | WO | disclosed |