Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 7/20 | 0.39 |
| ▸ | ABAT | P80404 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | F11 | P03951 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.33 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20852278 | 0.82 | TAAR1 (0.39) | TAAR1CA2 | |
| SCHEMBL16782403 | 0.76 | ALDH1A1 (0.42) | CA6CA14MAPT | |
| SCHEMBL171934 | 0.74 | ALDH1A1 (0.42) | CA1CA2CA7CA9MAPT | |
| SCHEMBL23254402 | 0.71 | — | — | |
| SCHEMBL21792294 | 0.69 | TYR (0.38) | MAPTADRB2 | |
| SCHEMBL22359687 | 0.68 | ADRB2 (0.42) | ADRB2 | |
| SCHEMBL15828 | 0.68 | HRH3 (0.79) | HRH3LOXL2ABATTAAR1LTA4H | |
| SCHEMBL22359670 | 0.67 | MAPT (0.43) | MAPT | |
| SCHEMBL19674446 | 0.67 | CYP2E1 (0.30) | — | |
| SCHEMBL295816 | 0.66 | ALDH1A1 (0.64) | HRH3LOXL2ABATMAPTKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3696181-A1 | PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS | Forma Therapeutics, Inc. (US) | 2020-08-19 | — | — | EP | disclosed |