SCHEMBL22360386

SCHEMBL22360386

N#CC(C#N)=NOCc1nc(-c2ccccc2Cl)no1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CASP3 P42574 1/20 0.53
SENP8 Q96LD8 1/20 0.53
SENP7 Q9BQF6 1/20 0.53
SENP6 Q9GZR1 1/20 0.53
FFAR1 O14842 1/20 0.48
ATM Q13315 1/20 0.48
HDAC1 Q13547 3/20 0.47
HDAC2 Q92769 2/20 0.47
HDAC8 Q9BY41 2/20 0.47
NPSR1 Q6W5P4 2/20 0.45
ALDH1A1 P00352 3/20 0.42
KMT2A Q03164 3/20 0.41
RAB9A P51151 3/20 0.41
NCOA1 Q15788 1/20 0.41
NCOA3 Q9Y6Q9 1/20 0.41
MAPT P10636 3/20 0.40
NPC1 O15118 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
TP53 P04637 2/20 0.40
TSHR P16473 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22360408 0.88 NPC1 (0.46) CASP3SENP8SENP7SENP6FFAR1
SCHEMBL22360407 0.86 MAPT (0.42) CASP3SENP8SENP7SENP6ALDH1A1
SCHEMBL22360385 0.86 SMN1; SMN2 (0.45) CASP3SENP8SENP7SENP6NPSR1
SCHEMBL22360377 0.83 RAB9A (0.55) CASP3SENP8SENP7SENP6FFAR1
SCHEMBL22360412 0.80 MAPT (0.42) CASP3SENP8SENP7SENP6FFAR1
SCHEMBL22360370 0.78 SMN1; SMN2 (0.57) CASP3SENP8SENP7SENP6NPSR1
SCHEMBL22360411 0.78 TSHR (0.39) CASP3SENP8SENP7SENP6FFAR1
SCHEMBL22360413 0.77 HDAC1 (0.43) CASP3SENP8SENP7SENP6FFAR1
SCHEMBL22360409 0.76 TDP1 (0.51) CASP3SENP8SENP7SENP6FFAR1
SCHEMBL22360388 0.74 ACLY (0.42) FFAR1KMT2ARAB9AMAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020164403-A1 1,1-DICYANO-OXIME-ETHER COMPOUND AND APPLICATION THEREOF 沈阳化工大学 2020-08-20 WO disclosed