SCHEMBL22360428

SCHEMBL22360428

Cc1cccc(-c2nnc(CON=C(C#N)C#N)s2)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.45
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
HPGD P15428 2/20 0.40
KDM4E B2RXH2 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
LMNA P02545 2/20 0.40
ATM Q13315 1/20 0.39
HSD17B1 P14061 1/20 0.38
RAB9A P51151 4/20 0.37
NPC1 O15118 3/20 0.37
PKM P14618 1/20 0.36
HSD17B13 Q7Z5P4 1/20 0.35
NPSR1 Q6W5P4 2/20 0.35
HRH3 Q9Y5N1 1/20 0.34
TRPM8 Q7Z2W7 1/20 0.34
CTSS P25774 1/20 0.34
CTSK P43235 1/20 0.34
USP2 O75604 1/20 0.34
TSHR P16473 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22360421 0.85 ALDH1A1 (0.40) ALDH1A1MEN1KMT2AHPGDKDM4E
SCHEMBL22360387 0.85 ALDH1A1 (0.40) ALDH1A1SMN1; SMN2HSD17B1RAB9ANPC1
SCHEMBL22360425 0.80 MAPT (0.44) ALDH1A1HPGDKDM4ELMNAMAPT
SCHEMBL22360415 0.79 ALDH1A1 (0.38) ALDH1A1MEN1KMT2AHPGDKDM4E
SCHEMBL22360426 0.79 KDM4E (0.45) ALDH1A1MEN1KMT2AHPGDKDM4E
SCHEMBL22360427 0.78 PTGS1 (0.30) HRH3
SCHEMBL22360417 0.78 HDAC1 (0.37) ALDH1A1MEN1KMT2AHPGDKDM4E
SCHEMBL22360430 0.77 NPC1 (0.39) ALDH1A1MEN1KMT2ANPC1NPSR1
SCHEMBL22360382 0.75 TP53 (0.52) ALDH1A1MEN1KMT2AHPGDKDM4E
SCHEMBL22360423 0.75 HDAC1 (0.40) ALDH1A1MEN1KMT2AKDM4ENPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020164403-A1 1,1-DICYANO-OXIME-ETHER COMPOUND AND APPLICATION THEREOF 沈阳化工大学 2020-08-20 WO disclosed