SCHEMBL22360421

SCHEMBL22360421

Cc1ccc(-c2nnc(CON=C(C#N)C#N)s2)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
LMNA P02545 1/20 0.40
GAA P10253 2/20 0.39
POLB P06746 2/20 0.39
MAPT P10636 2/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
HDAC1 Q13547 1/20 0.37
HDAC2 Q92769 1/20 0.37
GUSB P08236 1/20 0.37
ALOX15 P16050 1/20 0.34
PTGS2 P35354 1/20 0.34
HPGD P15428 3/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
RAB9A P51151 5/20 0.34
NPC1 O15118 2/20 0.34
KDM4E B2RXH2 1/20 0.33
SLC5A2 P31639 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22360426 0.88 KDM4E (0.45) ALDH1A1SMN1; SMN2LMNAMAPTHDAC1
SCHEMBL22360417 0.87 HDAC1 (0.37) ALDH1A1SMN1; SMN2LMNAGAAMAPT
SCHEMBL22360387 0.87 ALDH1A1 (0.40) ALDH1A1SMN1; SMN2GAAPOLBL3MBTL1
SCHEMBL22360428 0.85 ALDH1A1 (0.45) ALDH1A1SMN1; SMN2LMNAGAAMAPT
SCHEMBL22360423 0.84 HDAC1 (0.40) ALDH1A1GAAMAPTHDAC1HDAC2
SCHEMBL22360422 0.82 ALDH1A1 (0.41) ALDH1A1SMN1; SMN2GAAPOLBMAPT
SCHEMBL22360427 0.82 PTGS1 (0.30)
SCHEMBL22360425 0.81 MAPT (0.44) ALDH1A1LMNAGAAMAPTL3MBTL1
SCHEMBL22360415 0.80 ALDH1A1 (0.38) ALDH1A1SMN1; SMN2LMNAGAAPOLB
SCHEMBL22876743 0.78 L3MBTL1 (0.49) SMN1; SMN2GAAPOLBMAPTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020164403-A1 1,1-DICYANO-OXIME-ETHER COMPOUND AND APPLICATION THEREOF 沈阳化工大学 2020-08-20 WO disclosed