Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16923659 | 0.88 | CYP2D6 (0.43) | PAOXKDM4EALDH1A1TDP1MEN1 | |
| SCHEMBL16923658 | 0.84 | PAOX (0.42) | PAOXKDM4EALDH1A1TDP1MEN1 | |
| SCHEMBL15374964 | 0.84 | PAOX (0.42) | PAOXKDM4EALDH1A1TDP1MEN1 | |
| SCHEMBL18806447 | 0.83 | PAOX (0.38) | PAOXKDM4EALDH1A1TDP1MEN1 | |
| SCHEMBL15224088 | 0.82 | SLC18A3 (0.47) | PAOXKDM4EALDH1A1TDP1MEN1 | |
| SCHEMBL2628455 | 0.81 | PAOX (0.48) | PAOXDRD3HRH2HRH1USP2 | |
| SCHEMBL13457467 | 0.81 | PAOX (0.42) | PAOXNOS1 | |
| SCHEMBL12226462 | 0.79 | HSD11B1 (0.47) | PAOXKDM4EALDH1A1TDP1MEN1 | |
| SCHEMBL21440365 | 0.78 | DRD2 (0.39) | KDM4EALDH1A1HRH2HRH1HTR1A | |
| SCHEMBL25678038 | 0.77 | MAPK1 (0.42) | KDM4EALDH1A1TDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020168172-A1 | CONJUGATE COMPOUNDS FOR THE DEGRADATION OF RAF | ZAMBONI CHEM SOLUTIONS INC. (CA) | 2020-08-20 | — | — | WO | disclosed |