Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.94 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.58 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.52 |
| ▸ | TET3 | O43151 | 2/20 | 0.52 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.52 |
| ▸ | KDM4A | O75164 | 2/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL30566736 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2OR51E2SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL3229201 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2OR51E2SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL990702 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2OR51E2SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL9312234 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2OR51E2SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL17135308 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2OR51E2SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL4269585 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2OR51E2SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL9166463 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2OR51E2SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL7573228 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2OR51E2SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL7574683 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2OR51E2SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL10884230 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2OR51E2SLC22A6TET2TET3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4514306-A1 | OXIDATIVE HAIR-LIGHTENING AGENTS HAVING IMPROVED APPLICATION PROPERTIES FOR BLEACHING HAIR ROOTS | Henkel AG & Co. KGaA (DE) | 2025-03-05 | — | — | EP | disclosed |
| WO-2023208489-A1 | OXIDATIVE HAIR-LIGHTENING AGENTS HAVING IMPROVED APPLICATION PROPERTIES FOR BLEACHING HAIR ROOTS | HENKEL AG & CO. KGAA (DE) | 2023-11-02 | — | — | WO | disclosed |
| EP-2927254-B1 | PRODUCTION METHOD FOR POLYACETAL COPOLYMER | POLYPLASTICS CO (JP) | 2020-08-26 | — | — | EP | disclosed |
| CN-104592008-A | Preparation method of DL-sodium hydrogen malate | ANHUI SEALONG BIOTECHNOLOGY CO LTD | 2015-05-06 | — | — | CN | disclosed |