Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.94 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.58 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.52 |
| ▸ | TET3 | O43151 | 2/20 | 0.52 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.52 |
| ▸ | KDM4A | O75164 | 2/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL30566736 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2OR51E2SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL3229201 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2OR51E2SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL22360982 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2OR51E2SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL9312234 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2OR51E2SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL17135308 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2OR51E2SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL4269585 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2OR51E2SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL9166463 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2OR51E2SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL7573228 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2OR51E2SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL7574683 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2OR51E2SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL10884230 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2OR51E2SLC22A6TET2TET3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 131 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4626890-A1 | RIBOCICLIB SALTS AND FORMULATIONS THEREOF | KRKA, d.d., Novo mesto (SI) | 2025-10-08 | — | — | EP | claimed |
| WO-2024115680-A1 | RIBOCICLIB SALTS AND FORMULATIONS THEREOF | KRKA, D.D., NOVO MESTO (SI) | 2024-06-06 | — | — | WO | claimed |
| CN-116283957-A | Zolpidem hydrate and preparation method thereof | 山东新时代药业有限公司 | 2023-06-23 | — | — | CN | claimed |
| CN-102448963-B | Useful pharmaceutical salts of 7- [ (3R,4R) -3-hydroxy-4-hydroxymethyl-pyrrolidin-1-ylmethyl ] -3, 5-dihydro-pyrrolo [3,2-d ] pyrimidin-4-one | BIOCRYST PHARM INC | 2015-06-17 | — | — | CN | claimed |
| CN-102448963-A | Useful pharmaceutical salts of 7- [ (3R,4R) -3-hydroxy-4-hydroxymethyl-pyrrolidin-1-ylmethyl ] -3, 5-dihydro-pyrrolo [3,2-d ] pyrimidin-4-one | BIOCRYST PHARM INC | 2012-05-09 | — | — | CN | claimed |
| US-8039485-B2 | Malate salts, and polymorphs of (3S,5S)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid | WARNER CHILCOTT COMPANY, LLC (US) | 2011-10-18 | — | — | US | claimed |
| EP-2001862-B1 | MALATE SALTS, AND POLYMORPHS OF (3S,5S)-7-[3-AMINO-5-METHYL-PIPERIDINYL]-1-CYCLOPROPYL-1,4-DIHYDRO-8-METHOXY-4-OXO-3-QUINOLINECARBOXYLIC ACID | WARNER CHILCOTT CO LLC (PR) | 2011-04-27 | — | — | EP | claimed |
| WO-2009007999-A2 | A NON DUSTY, FREE FLOWING, STORAGE STABLE SOLID COMPOSITION AND A PROCESS FOR ITS PREPARATION | UNITED PHOSPHORUS LIMTED (IN) | 2009-01-15 | — | — | WO | claimed |
| US-20080312320-A1 | Non-dusty, free flowing, storage stable solid composition and a process for its preparation | UNITED PHOSPHORUS, INC. (US) | 2008-12-18 | — | — | US | claimed |
| EP-2001862-A2 | MALATE SALTS, AND POLYMORPHS OF (3S,5S)-7-Ý3-AMINO-5-METHYL-PIPERIDINYL¨-1-CYCLOPROPYL-1,4-DIHYDRO-8-METHOXY-4-OXO-3-QUINOLINECARBOXYLIC ACID | The Procter and Gamble Company (US) | 2008-12-17 | — | — | EP | claimed |
| EP-0609247-B1 | SKIN CLEANSER | SMITHKLINE BEECHAM CORP (US) | 2000-08-09 | — | — | EP | claimed |
| CN-1040434-C | Heterobicyclic compounds | RECORDATI CHEM PHARM (CH) | 1998-10-28 | — | — | CN | claimed |
| US-5811107-A | Skin cleanser | SMITHKLINE BEECHAM CORPORATION (US) | 1998-09-22 | — | — | US | claimed |
| US-5723539-A | POLYMER BLEND WITH POLYCARBOXYLIC ACID FOR IMPACT STRENGTH, CHEMICAL RESISTANCE AND PROCESSABILITY | GENERAL ELECTRIC (US) | 1998-03-03 | — | — | US | claimed |
| US-5719233-A | BLEND ALSO CONTAINING (PARTIALLY) HYDROGENATED VINYL AROMATIC CONJUGATED DIENE BLOCK POLYMER AND ONE OR MORE ALIPHATIC POLYCARBOXYLIC ACIDS OR ESTER OR AMIDE DERIVATIVES | GENERAL ELECTRIC COMPANY (US) | 1998-02-17 | — | — | US | claimed |
| EP-0609247-A4 | SKIN CLEANSER. | SMITHKLINE BEECHAM CORP (US) | 1994-11-17 | — | — | EP | claimed |
| EP-0609247-A1 | SKIN CLEANSER | SMITHKLINE BEECHAM CORPORATION (US) | 1994-08-10 | — | — | EP | claimed |
| WO-1993005893-A1 | SKIN CLEANSER | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-01 | — | — | WO | claimed |
| US-5120801-A | Impact strength, ductility | GENERAL ELECTRIC CO. (US) | 1992-06-09 | — | — | US | claimed |
| US-5000897-A | Copolymerization of polyamides and polyethers after blending for improved impact strength | GENERAL ELECTRIC COMPANY (US) | 1991-03-19 | — | — | US | claimed |