Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.35 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.35 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CHKA | P35790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2064262 | 0.81 | KMT2A (0.64) | MEN1KMT2AHRH3SIGMAR1MC4R | |
| SCHEMBL27991037 | 0.80 | SIGMAR1 (0.40) | MEN1KMT2ASIGMAR1MC4RLMNA | |
| SCHEMBL738784 | 0.78 | HRH3 (0.67) | HRH3HRH4NCF1ALDH1A1KDM4E | |
| SCHEMBL7356340 | 0.78 | HRH3 (0.60) | MEN1KMT2AHRH3SIGMAR1HRH4 | |
| SCHEMBL28089650 | 0.78 | ALDH1A1 (0.58) | MEN1KMT2AHRH3LMNAALDH1A1 | |
| SCHEMBL3621186 | 0.78 | LMNA (0.62) | MEN1KMT2AHRH3SIGMAR1HRH4 | |
| SCHEMBL22361103 | 0.77 | MEN1 (0.40) | MEN1KMT2AMC4RLMNAALDH1A1 | |
| SCHEMBL742562 | 0.77 | MC4R (0.66) | HRH3SIGMAR1MC4RNCF1LMNA | |
| SCHEMBL447560 | 0.76 | HRH3 (0.71) | HRH3HRH4NCF1ALDH1A1KDM4E | |
| SCHEMBL996532 | 0.76 | HRH3 (0.71) | HRH3HRH4NCF1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3250572-B1 | SUBSTITUTED IMIDAZO [1, 2-A]PYRIDIN-2-YLAMINE COMPOUNDS, AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | SHANGHAI FUDAN ZHANGJIANG BIO PHARMACEUTICAL CO LTD (CN) | 2020-08-26 | — | — | EP | disclosed |