Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPY1R | P25929 | 1/20 | 0.33 |
| ▸ | NPY2R | P49146 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.33 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2235300 | 1.00 | TLR4 (0.52) | TLR4KMT2AACLYNPC1RAB9A | |
| SCHEMBL14108316 | 1.00 | TLR4 (0.52) | TLR4KMT2AACLYNPC1RAB9A | |
| SCHEMBL27985939 | 0.89 | ACLY (0.40) | TLR4ACLYNPC1RAB9APOLB | |
| SCHEMBL2238499 | 0.85 | TLR4 (0.74) | TLR4KMT2ALMNANPSR1MRGPRX1 | |
| SCHEMBL2234657 | 0.85 | TLR4 (0.74) | TLR4KMT2ALMNANPSR1MRGPRX1 | |
| SCHEMBL871856 | 0.85 | TLR4 (0.74) | TLR4KMT2ALMNANPSR1MRGPRX1 | |
| SCHEMBL27592449 | 0.83 | TLR4 (0.72) | TLR4KMT2AACLYNPC1RAB9A | |
| SCHEMBL872269 | 0.81 | TLR4 (0.73) | TLR4KMT2AACLYNPC1RAB9A | |
| SCHEMBL3690868 | 0.81 | TLR4 (0.73) | TLR4KMT2AACLYNPC1RAB9A | |
| SCHEMBL722368 | 0.81 | TLR4 (0.73) | TLR4KMT2AACLYNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1209149-B9 | SUBSTITUTED AROMATIC-RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME, AND USE | TAKEDA PHARMACEUTICAL (JP) | 2011-08-31 | — | — | EP | claimed |
| EP-1209149-B1 | SUBSTITUTED AROMATIC-RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME, AND USE | TAKEDA PHARMACEUTICAL (JP) | 2010-09-29 | — | — | EP | claimed |
| EP-2528598-A1 | COMPOUNDS FOR SUPPRESSING A PERIPHERAL NERVE DISORDER INDUCED BY AN ANTI - CANCER AGENT | Takeda Pharmaceutical Company Limited (JP) | 2012-12-05 | — | — | EP | disclosed |
| CN-102670503-A | Stable emulsion composition | TAKEDA PHARMACEUTICAL | 2012-09-19 | — | — | CN | disclosed |
| WO-2011093512-A1 | COMPOUNDS FOR SUPPRESSING A PERIPHERAL NERVE DISORDER INDUCED BY AN ANTI - CANCER AGENT | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-08-04 | — | — | WO | disclosed |
| CN-101212986-A | stable emulsified composition | TAKEDA PHARMACEUTICAL (JP) | 2008-07-02 | — | — | CN | disclosed |