Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.45 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP3 | P08254 | 2/20 | 0.44 |
| ▸ | MMP13 | P45452 | 2/20 | 0.44 |
| ▸ | MMP14 | P50281 | 2/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL29447008 | 0.94 | CHRM1 (0.49) | ADAMTS4ADAMTS5HDAC3HDAC1HDAC2 | |
| Trifluoroacetic Acid SCHEMBL22777600 | 0.94 | CHRM1 (0.49) | ADAMTS4ADAMTS5HDAC3HDAC1HDAC2 | |
| SCHEMBL8251733 | 0.93 | ADAMTS4 (0.50) | ADAMTS4ADAMTS5HDAC3HDAC1HDAC2 | |
| SCHEMBL22373887 | 0.93 | ADAMTS4 (0.50) | ADAMTS4ADAMTS5HDAC3HDAC1HDAC2 | |
| SCHEMBL23920228 | 0.86 | CHRM1 (0.55) | ADAMTS4ADAMTS5HDAC3HDAC1HDAC2 | |
| SCHEMBL30578718 | 0.86 | CHRM1 (0.55) | ADAMTS4ADAMTS5HDAC3HDAC1HDAC2 | |
| Trifluoroacetic Acid SCHEMBL22362300 | 0.83 | HDAC3 (0.45) | ADAMTS4ADAMTS5HDAC3HDAC1HDAC2 | |
| Trifluoroacetic Acid SCHEMBL21819415 | 0.82 | RAB9A (0.50) | ADAMTS4ADAMTS5HDAC3HDAC1HDAC2 | |
| Trifluoroacetic Acid SCHEMBL22362286 | 0.80 | SCN9A (0.50) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Trifluoroacetic Acid SCHEMBL22777545 | 0.76 | ATF4 (0.49) | HDAC3HDAC1HDAC2HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3930697-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC (US) | 2022-01-05 | — | — | EP | disclosed |
| CN-113840597-A | Integrated stress response pathway inhibitors | 普拉西斯生物技术有限责任公司 | 2021-12-24 | — | — | CN | disclosed |
| US-20200270232-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ALTOS LABS, INC. | 2020-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200270232-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, DDIT3, ATF1 | ADAMTS4 4342/4885ADAMTS5 4307/4885HDAC3 1173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.