Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.45 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 4/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2237331 | 0.93 | ALDH1A1 (0.55) | OPRM1ALDH1A1KDM4ELTA4HMCHR1 | |
| SCHEMBL2238599 | 0.93 | OPRM1 (0.51) | OPRM1ALDH1A1KDM4EGAALMNA | |
| SCHEMBL1935385 | 0.90 | S1PR1 (0.45) | OPRM1ALDH1A1S1PR4S1PR1S1PR3 | |
| SCHEMBL2314469 | 0.88 | OPRM1 (0.46) | OPRM1S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL2237167 | 0.87 | OPRM1 (0.48) | OPRM1S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL2239987 | 0.87 | OPRM1 (0.48) | OPRM1S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL2234975 | 0.85 | OPRM1 (0.44) | OPRM1S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL2237887 | 0.85 | S1PR1 (0.45) | OPRM1S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL1936100 | 0.84 | S1PR5 (0.49) | OPRM1ALDH1A1S1PR4S1PR1S1PR3 | |
| SCHEMBL2239925 | 0.83 | MCHR1 (0.50) | OPRM1LTA4HCD274MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110201589-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC AG (DE) | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201589-A1 | NEW BRADYKININ B1 ANTAGONISTS | BDKRB1, BDKRB2, BRS3 | OPRM1 442/4885ALDH1A1 3363/4885S1PR4 676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.