Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 18/20 | 0.58 |
| ▸ | TPH2 | Q8IWU9 | 18/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22365623 | 0.74 | TPH2 (0.60) | TPH1TPH2MEN1KMT2AALDH1A1 | |
| SCHEMBL19810137 | 0.74 | TPH1 (1.00) | TPH1TPH2 | |
| SCHEMBL19827282 | 0.72 | TPH2 (0.62) | TPH1TPH2 | |
| SCHEMBL19810122 | 0.71 | TPH1 (1.00) | TPH1TPH2 | |
| SCHEMBL20707674 | 0.68 | TPH1 (0.59) | TPH1TPH2MAPTALDH1A1 | |
| SCHEMBL21027845 | 0.67 | TPH1 (0.57) | TPH1TPH2 | |
| SCHEMBL19817378 | 0.65 | TPH1 (1.00) | TPH1TPH2 | |
| SCHEMBL19827159 | 0.65 | TPH1 (0.74) | TPH1TPH2 | |
| SCHEMBL19813989 | 0.65 | TPH1 (1.00) | TPH1TPH2 | |
| SCHEMBL19817335 | 0.65 | TPH1 (1.00) | TPH1TPH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3490996-B1 | XANTHINE DERIVATIVES, THEIR USE AS A MEDICAMENT, AND PHARMACEUTICAL PREPARATIONS COMPRISING THE SAME | MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN (DE) | 2020-08-26 | — | — | EP | disclosed |