Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 18/20 | 0.57 |
| ▸ | TPH2 | Q8IWU9 | 18/20 | 0.57 |
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21027606 | 0.87 | TPH1 (0.63) | TPH1TPH2PDE5A | |
| SCHEMBL21027604 | 0.77 | TPH1 (0.58) | TPH1TPH2 | |
| SCHEMBL19810137 | 0.73 | TPH1 (1.00) | TPH1TPH2 | |
| SCHEMBL19810122 | 0.71 | TPH1 (1.00) | TPH1TPH2 | |
| SCHEMBL21027610 | 0.69 | TPH2 (0.63) | TPH1TPH2 | |
| SCHEMBL22105455 | 0.68 | KMT2A (0.33) | PDE5A | |
| SCHEMBL22365667 | 0.67 | TPH1 (0.58) | TPH1TPH2 | |
| SCHEMBL19827112 | 0.67 | TPH1 (1.00) | TPH1TPH2 | |
| SCHEMBL22105567 | 0.66 | TSHR (0.45) | — | |
| SCHEMBL19827159 | 0.64 | TPH1 (0.74) | TPH1TPH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10683309-B2 | Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same | Max-Delbrück-Centrum für Molekulare Medizin (DE) | 2020-06-16 | — | — | US | disclosed |
| US-20190161503-A1 | XANTHINE DERIVATIVES, THEIR USE AS A MEDICAMENT, AND PHARMACEUTICAL PREPARATIONS COMPRISING THE SAME | Max-Delbrück-Centrum für Molekulare Medizin (DE) | 2019-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10683309-B2 | Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same | TPH1, XDH, TPH2 | TPH1 1/4885TPH2 3/4885PDE5A 286/4885 |
| US-20190161503-A1 | XANTHINE DERIVATIVES, THEIR USE AS A MEDICAMENT, AND PHARMACEUTICAL PREPARATIONS COMPRISING THE SAME | TPH1, XDH, TPH2 | TPH1 1/4885TPH2 3/4885PDE5A 286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.