Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.46 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 3/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.42 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29644391 | 0.89 | ALDH1A1 (0.49) | ESR2SCN9AMAPK1NR1H2UCHL1 | |
| SCHEMBL16269236 | 0.89 | ALDH1A1 (0.49) | ESR2SCN9AMAPK1NR1H2UCHL1 | |
| SCHEMBL16269608 | 0.89 | UCHL1 (0.49) | ESR2SCN9AMAPK1NR1H2UCHL1 | |
| SCHEMBL22366387 | 0.85 | S1PR5 (0.42) | ABHD6 | |
| SCHEMBL10289745 | 0.85 | ESR2 (0.53) | ESR2SCN9AMAPK1NR1H2UCHL1 | |
| SCHEMBL22366367 | 0.84 | ESR2 (0.51) | ESR2SCN9AMAPK1NR1H2UCHL1 | |
| SCHEMBL30428708 | 0.84 | ESR2 (0.51) | ESR2SCN9AMAPK1NR1H2UCHL1 | |
| SCHEMBL5774734 | 0.84 | UCHL1 (0.53) | ESR2SCN9AMAPK1NR1H2UCHL1 | |
| SCHEMBL29554603 | 0.84 | UCHL1 (0.53) | ESR2SCN9AMAPK1NR1H2UCHL1 | |
| SCHEMBL22530017 | 0.83 | ESR2 (0.51) | ESR2SCN9AMAPK1NR1H2UCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3700911-B1 | NOVEL MACROCYCLIC DERIVATIVES, PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SERVIER LAB (FR) | 2023-09-06 | — | — | EP | disclosed |
| EP-3700911-A1 | NOVEL MACROCYCLIC DERIVATIVES, PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Les Laboratoires Servier SAS (FR) | 2020-09-02 | — | — | EP | disclosed |