Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | ABHD6 | Q9BV23 | 4/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CPT2 | P23786 | 1/20 | 0.37 |
| ▸ | CPT1A | P50416 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28245902 | 0.86 | S1PR5 (0.51) | S1PR5NOTUMABHD6TAAR1GAA | |
| SCHEMBL22366365 | 0.85 | ESR2 (0.46) | ABHD6 | |
| SCHEMBL22319819 | 0.80 | S1PR5 (0.47) | S1PR5NOTUMABHD6TAAR1ALDH1A1 | |
| SCHEMBL18584701 | 0.79 | ABHD6 (0.43) | S1PR5NOTUMABHD6TAAR1ALDH1A1 | |
| SCHEMBL28901639 | 0.78 | ABHD6 (0.41) | S1PR5NOTUMABHD6TAAR1GAA | |
| SCHEMBL16268894 | 0.78 | S1PR5 (0.40) | S1PR5NOTUMABHD6TAAR1ALDH1A1 | |
| SCHEMBL22319890 | 0.78 | S1PR5 (0.41) | S1PR5NOTUMABHD6TAAR1ALDH1A1 | |
| SCHEMBL5777006 | 0.78 | SMN1; SMN2 (0.44) | NOTUMABHD6TAAR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5775730 | 0.75 | KDM4E (0.39) | ABHD6TAAR1GAAPTGER4PTGER2 | |
| SCHEMBL16269608 | 0.75 | UCHL1 (0.49) | S1PR5ABHD6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3700911-B1 | NOVEL MACROCYCLIC DERIVATIVES, PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SERVIER LAB (FR) | 2023-09-06 | — | — | EP | disclosed |
| EP-3700911-A1 | NOVEL MACROCYCLIC DERIVATIVES, PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Les Laboratoires Servier SAS (FR) | 2020-09-02 | — | — | EP | disclosed |