Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.43 |
| ▸ | PGR | P06401 | 7/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | AR | P10275 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CNKSR1 | Q969H4 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11364366 | 0.83 | PTGS1 (0.46) | ALDH1A1KDM4EHSD17B10PGRMAPT | |
| SCHEMBL9645804 | 0.82 | ALDH1A1 (0.51) | ALDH1A1KDM4EHSD17B10ALOX15MAPK1 | |
| SCHEMBL11380056 | 0.81 | PTGS1 (0.45) | ALDH1A1KDM4EHSD17B10PGRMAPT | |
| SCHEMBL22319850 | 0.80 | CYP4F2 (0.44) | ALDH1A1KDM4EHSD17B10ALOX15PGR | |
| SCHEMBL22319938 | 0.79 | AR (0.43) | PGRAR | |
| SCHEMBL30540310 | 0.75 | PGR (0.43) | PGRAR | |
| SCHEMBL11368034 | 0.73 | HPGD (0.49) | ALDH1A1PGRHPGDARTSHR | |
| SCHEMBL11380054 | 0.73 | HPGD (0.46) | ALDH1A1PGRHPGDARTSHR | |
| SCHEMBL3426087 | 0.72 | ALDH1A1 (0.44) | ALDH1A1KDM4EHSD17B10ALOX15MAPK1 | |
| SCHEMBL12763830 | 0.72 | AR (0.45) | PGRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3700911-B1 | NOVEL MACROCYCLIC DERIVATIVES, PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SERVIER LAB (FR) | 2023-09-06 | — | — | EP | disclosed |
| EP-3700911-A1 | NOVEL MACROCYCLIC DERIVATIVES, PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Les Laboratoires Servier SAS (FR) | 2020-09-02 | — | — | EP | disclosed |