Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 11/20 | 0.44 |
| ▸ | AR | P10275 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11380056 | 0.98 | PTGS1 (0.45) | PTGS1PTGS2CXCL8AKR1B1GLO1 | |
| SCHEMBL30540310 | 0.84 | PGR (0.43) | PGRAR | |
| SCHEMBL22366377 | 0.83 | ALDH1A1 (0.43) | PGRARKDM4EALDH1A1MAPT | |
| SCHEMBL11380054 | 0.83 | HPGD (0.46) | PGRARALDH1A1HPGD | |
| SCHEMBL11368034 | 0.83 | HPGD (0.49) | PGRARALDH1A1HPGD | |
| SCHEMBL68487 | 0.80 | PTGS2 (0.58) | PTGS1PTGS2CXCL8AKR1B1GLO1 | |
| SCHEMBL11371602 | 0.79 | KDM4E (0.41) | PTGS1PTGS2CXCL8AKR1B1GLO1 | |
| SCHEMBL6653296 | 0.77 | AR (0.46) | PGRAR | |
| SCHEMBL11370743 | 0.77 | PGR (0.41) | PGRKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL12763830 | 0.75 | AR (0.45) | PGRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4246176-A | Synthesis of 5-aroyl-1-hydrocarbylpyrrole-2-acetic acid | ETHYL CORPORATION (US) | 1981-01-20 | — | — | US | claimed |
| US-4238396-A | REACTING THE 5-CYANO DERIVATIVE WITH A GRIGNARD REAGENT FOLLOWED BY HYDROLYSIS TO OBTAIN THE 5-ACYL | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1980-12-09 | — | — | US | claimed |
| JP-54081264-A | — | — | None | — | — | JP | disclosed |
| JP-55087769-A | — | — | None | — | — | JP | disclosed |
| US-11833162-B2 | Macrocyclic derivatives, process for preparing same and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2023-12-05 | — | — | US | disclosed |
| EP-3700911-B1 | NOVEL MACROCYCLIC DERIVATIVES, PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SERVIER LAB (FR) | 2023-09-06 | — | — | EP | disclosed |
| EP-3700911-A1 | NOVEL MACROCYCLIC DERIVATIVES, PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Les Laboratoires Servier SAS (FR) | 2020-09-02 | — | — | EP | disclosed |
| US-20200253993-A1 | NOVEL MACROCYCLIC DERIVATIVES, PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2020-08-13 | — | — | US | disclosed |
| US-4246176-A | Synthesis of 5-aroyl-1-hydrocarbylpyrrole-2-acetic acid | ETHYL CORPORATION (US) | 1981-01-20 | — | — | US | disclosed |
| US-4246175-A | CYANATION OF 2,2,2-TRICHLORO-1-(N-HYDROCARBYLPYRRYL-2)-ETHANOL | ETHYL CORPORATION (US) | 1981-01-20 | — | — | US | disclosed |
| US-4238396-A | REACTING THE 5-CYANO DERIVATIVE WITH A GRIGNARD REAGENT FOLLOWED BY HYDROLYSIS TO OBTAIN THE 5-ACYL | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1980-12-09 | — | — | US | disclosed |
| JP-S5587769-A | PREPARATION OF PYRROLEACETIC ACID DERIVATIVE | SAGAMI CHEM RES CENTER | 1980-07-02 | — | — | JP | disclosed |
| WO-1979000357-A1 | PROCESS FOR THE PRODUCTION OF 1-METHYL-5-ACROYLPYROL-2-ACETIC ACID | SAGAMI CHEM RES (JP) | 1979-06-28 | — | — | WO | disclosed |
| JP-S5481264-A | PREPARATION OF 1-METHYL-5-AROYLPRYRROLE-2-ACETIC ACID | SAGAMI CHEM RES CENTER | 1979-06-28 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11833162-B2 | Macrocyclic derivatives, process for preparing same and pharmaceutical compositions containing same | C1R, F12, RDX | PTGS1 452/4885PTGS2 841/4885CXCL8 2018/4885 |
| US-20200253993-A1 | NOVEL MACROCYCLIC DERIVATIVES, PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | C1R, RDX, F12 | PTGS1 520/4885PTGS2 876/4885CXCL8 2619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.