Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 13/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.33 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22366564 | 0.99 | ABCG2 (0.42) | ABCG2APAF1XDHPLK1DYRK1A | |
| Bromide SCHEMBL22366567 | 0.90 | APAF1 (0.39) | ABCG2APAF1XDHPLK1DYRK1A | |
| SCHEMBL22366571 | 0.72 | ABCG2 (0.46) | ABCG2ABCB1 | |
| Bromide SCHEMBL31337681 | 0.70 | KDM4E (0.43) | ABCG2 | |
| SCHEMBL16882287 | 0.69 | XDH (0.45) | APAF1XDHCA2 | |
| SCHEMBL31337688 | 0.69 | KDM4E (0.42) | ABCG2 | |
| Bromide SCHEMBL2214307 | 0.68 | XDH (0.60) | APAF1XDHCA2 | |
| SCHEMBL13554658 | 0.68 | ABCG2 (0.53) | ABCG2 | |
| SCHEMBL16355119 | 0.68 | ABCG2 (0.53) | ABCG2 | |
| SCHEMBL2218265 | 0.67 | XDH (0.57) | APAF1XDHCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12055517-B2 | Graphene transistor comprising functionalized N-heterocyclic carbene compound, fabrication method therefor, and biosensor comprising same | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2024-08-06 | — | — | US | disclosed |
| EP-3703134-B1 | BIOSENSOR COMPRISING GRAPHENE TRANSISTOR FUNCTIONALIZED WITH N-HETEROCYCLIC CARBENE COMPOUND AND FABRICATION METHOD THEREFOR | KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR) | 2024-04-17 | — | — | EP | disclosed |
| US-20210181147-A1 | GRAPHENE TRANSISTOR COMPRISING FUNCTIONALIZED N-HETEROCYCLIC CARBENE COMPOUND, FABRICATION METHOD THEREFOR, AND BIOSENSOR COMPRISING SAME | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2021-06-17 | — | — | US | disclosed |
| EP-3703134-A1 | GRAPHENE TRANSISTOR COMPRISING FUNCTIONALIZED N-HETEROCYCLIC CARBENE COMPOUND, FABRICATION METHOD THEREFOR, AND BIOSENSOR COMPRISING SAME | Korea Research Institute of Bioscience and Biotechnology (KR) | 2020-09-02 | — | — | EP | disclosed |