Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.35 |
| ▸ | PLK1 | P53350 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.34 |
| ▸ | PLK2 | Q9NYY3 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 3/20 | 0.33 |
| ▸ | PPARD | Q03181 | 3/20 | 0.33 |
| ▸ | PPARA | Q07869 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL22366565 | 0.90 | ABCG2 (0.41) | APAF1XDHPLA2G2APLK1DYRK1A | |
| SCHEMBL22366564 | 0.89 | ABCG2 (0.42) | APAF1XDHPLA2G2APLK1DYRK1A | |
| SCHEMBL22179015 | 0.71 | GAA (0.37) | ABCG2 | |
| SCHEMBL16882287 | 0.71 | XDH (0.45) | APAF1XDHCA2CA1 | |
| Bromide SCHEMBL2214307 | 0.70 | XDH (0.60) | APAF1XDHCA2CA1 | |
| SCHEMBL2218265 | 0.68 | XDH (0.57) | APAF1XDHCA2CA1 | |
| SCHEMBL27522153 | 0.67 | KCNA3 (0.61) | KCNA3 | |
| SCHEMBL23366511 | 0.65 | ADRB2 (0.33) | — | |
| SCHEMBL29206245 | 0.65 | KCNA3 (0.59) | KCNA3 | |
| SCHEMBL15923485 | 0.65 | KCNA3 (0.59) | KCNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111837239-B | Graphene transistor comprising a functional N-heterocyclic carbene compound, method of preparing the same, and biosensor comprising the same | 韩国生命工学研究院 | 2024-11-26 | — | — | CN | disclosed |
| US-12055517-B2 | Graphene transistor comprising functionalized N-heterocyclic carbene compound, fabrication method therefor, and biosensor comprising same | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2024-08-06 | — | — | US | disclosed |
| EP-3703134-B1 | BIOSENSOR COMPRISING GRAPHENE TRANSISTOR FUNCTIONALIZED WITH N-HETEROCYCLIC CARBENE COMPOUND AND FABRICATION METHOD THEREFOR | KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR) | 2024-04-17 | — | — | EP | disclosed |
| US-20210181147-A1 | GRAPHENE TRANSISTOR COMPRISING FUNCTIONALIZED N-HETEROCYCLIC CARBENE COMPOUND, FABRICATION METHOD THEREFOR, AND BIOSENSOR COMPRISING SAME | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2021-06-17 | — | — | US | disclosed |
| CN-111837239-A | Graphene transistor comprising functional N-heterocyclic carbene compound, method for preparing the same, and biosensor comprising the same | 韩国生命工学研究院 | 2020-10-27 | — | — | CN | disclosed |
| EP-3703134-A1 | GRAPHENE TRANSISTOR COMPRISING FUNCTIONALIZED N-HETEROCYCLIC CARBENE COMPOUND, FABRICATION METHOD THEREFOR, AND BIOSENSOR COMPRISING SAME | Korea Research Institute of Bioscience and Biotechnology (KR) | 2020-09-02 | — | — | EP | disclosed |