Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23053830 | 0.68 | KDM1A (0.42) | ALDH1A1BRD4KDM4EKDM1A | |
| SCHEMBL7936463 | 0.67 | BRD4 (0.39) | BRD4PDE7A | |
| SCHEMBL1699423 | 0.66 | PIM1 (0.43) | ALDH1A1MAPK1SMN1; SMN2BRD4KDM4E | |
| SCHEMBL30422252 | 0.66 | BRD4 (0.39) | BRD4 | |
| SCHEMBL13360866 | 0.66 | BRD4 (0.39) | BRD4 | |
| SCHEMBL19518238 | 0.63 | CREBBP (0.61) | ALDH1A1BRD4 | |
| SCHEMBL16315955 | 0.63 | CYP1A2 (0.33) | HTTKDM4E | |
| SCHEMBL15773405 | 0.62 | HSD11B1 (0.48) | — | |
| SCHEMBL2968862 | 0.61 | ALDH1A1 (0.38) | ALDH1A1CYP3A4CYP2D6CYP2C9LMNA | |
| SCHEMBL1073565 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204360-B1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2020-08-26 | — | — | EP | disclosed |