Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.63 |
| ▸ | CREBBP | Q92793 | 5/20 | 0.63 |
| ▸ | MAOB | P27338 | 7/20 | 0.51 |
| ▸ | MAOA | P21397 | 2/20 | 0.51 |
| ▸ | PARP15 | Q460N3 | 4/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22368731 | 0.80 | BRD4 (0.63) | BRD4CREBBPMAOBMAOAPDE3B | |
| SCHEMBL23189095 | 0.80 | BRD4 (0.45) | BRD4CREBBPMAOBMAOADRD2 | |
| SCHEMBL31718484 | 0.79 | MAOA (0.61) | BRD4CREBBPMAOBMAOAPARP15 | |
| SCHEMBL22369086 | 0.79 | MAOB (0.65) | BRD4CREBBPMAOBMAOANPC1 | |
| SCHEMBL15964652 | 0.78 | PDE3B (0.50) | MAOBMAOADRD2PDE3BPDE3A | |
| SCHEMBL17680692 | 0.78 | CREBBP (1.00) | BRD4CREBBPMAOBMAOAPARP15 | |
| SCHEMBL22368891 | 0.77 | BRD4 (0.64) | BRD4CREBBPMAOBMAOANPC1 | |
| SCHEMBL22369077 | 0.75 | BRD4 (0.66) | BRD4CREBBPMAOBMAOAPARP10 | |
| SCHEMBL22368812 | 0.75 | BRD4 (0.70) | BRD4CREBBPMAOBMAOAPARP15 | |
| SCHEMBL15964938 | 0.75 | BRD4 (0.40) | BRD4CREBBPMAOBPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204360-B1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2020-08-26 | — | — | EP | disclosed |