Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 10/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17680850 | 0.81 | OPRK1 (0.36) | OPRK1ABL1CNR2 | |
| SCHEMBL1173515 | 0.71 | DGAT1 (0.38) | ABL1 | |
| SCHEMBL29498804 | 0.71 | NAPRT (0.46) | OPRK1 | |
| SCHEMBL1516793 | 0.71 | NAPRT (0.46) | OPRK1 | |
| SCHEMBL26023823 | 0.71 | DGAT1 (0.36) | OPRK1ABL1 | |
| SCHEMBL27309635 | 0.70 | HRH3 (0.33) | HRH3ABL1 | |
| SCHEMBL25335179 | 0.69 | DGAT1 (0.52) | — | |
| SCHEMBL9648890 | 0.69 | OPRK1 (0.42) | OPRK1 | |
| SCHEMBL21815554 | 0.69 | ALDH1A1 (0.35) | OPRK1 | |
| SCHEMBL31356591 | 0.69 | OPRK1 (0.42) | OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204360-B1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2020-08-26 | — | — | EP | disclosed |
| US-9453027-B2 | Deuterium-enriched pyridinonecarboxamides and derivatives | DHANOA DALJIT SINGH (US) | 2016-09-27 | — | — | US | disclosed |